OAS3

Gene Symbol	OAS3
Entrez Gene	4940
Alt Symbol	p100, p100OAS
Species	Human
Gene Type	protein-coding
Description	2'-5'-oligoadenylate synthetase 3, 100kDa
Other Description	(2-5')oligo(A) synthase 3|(2-5')oligo(A) synthetase 3|2'-5'-oligoadenylate synthase 3|2'-5'oligoadenylate synthetase p100|2-5A synthase 3|2-5A synthetase 3|p100 OAS
Swissprots	Q9Y6K5 Q9H3P5 Q2HJ14
Accessions	CBI67637 CBI70412 CDI30182 EAW98024 EAW98025 Q9Y6K5 AB044545 BAB18647 AF063613 AAD28543 AK000608 AK292949 BAF85638 BC012015 BC113746 AAI13747 BG390192 BG765554 BM474470 BU558279 BU860096 W47620 XM_005253889 XP_005253946 NM_006187 NP_006178
Function	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}.
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Present at high level in placenta trophoblast.
Top Pathways	Hepatitis C, Measles, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human OAS3 / p100 ELISA Kit (Sandwich ELISA) - LS-F8121 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human OAS3 / p100 ELISA Kit (Sandwich ELISA) - LS-F12206 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.156-10 ng/ml

Human OAS3 ELISA Kit - abx152575 from Abbexa Category ELISA Kit Sensitivity 2.27 ng/ml Range 6.25 ng/ml - 400 ng/ml

2',5'-Oligoadenylate Synthetase 3 (OAS3), Human, ELISA Kit - SEF690Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 2.27ng/mL Range 6.25-400ng/mL

2'-5'-oligoadenylate synthase 3, OAS3, Human, ELISA Kit - E1715h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3) - SEF690Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.067ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3) - SEF690Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.067ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat OAS3 / p100 ELISA Kit (Custom ELISA) - LS-F18345 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse OAS3 / p100 ELISA Kit (Sandwich ELISA) - LS-F18344 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Human 2'-5'-oligoadenylate synthase 3 ELISA Kit - abx251212 from Abbexa Category ELISA Kit Range 0.78 ng/ml - 50 ng/ml

2,5-Oligoadenylate Synthetase 3 (OAS3), Human, ELISA Kit - DL-OAS3-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 6.25-400 ng/mL

Human OAS3 ELISA Kit - abx575899 from Abbexa Category ELISA Kit Sensitivity 2.27 ng/ml Range 6.25 ng/ml - 400 ng/ml

Human 2'-5'-oligoadenylate synthase 3 ELISA Kit - EKE52796 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.34 ng/mL Range 0.78-50 ng/mL

OAS3 - EKH3790 from Nordic BioSite Sensitivity 0.469ng/ml Range 0.78-50ng/ml

OAS3 ELISA Kit (Human) (OKEH01231) - OKEH01231 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.34 ng/mL Range 0.78 - 50 ng/mL

Human OAS3 ELISA Kit - E041788 from Biobool Category ELISA Kit Sensitivity Typically less than 0.067ng/mL.

Human 2'-5'-oligoadenylate synthase 3 ELISA Kit - EK3902 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 0.156-10 ng/mL

2',5'-Oligoadenylate Synthetase 3 (OAS3), ELISA Kit - MBS452029 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.27ng/mL Range 6.25-400ng/mL

2'-5'-oligoadenylate synthase 3, ELISA Kit - MBS9427732 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.34ng/mL Range 0.78-50 ng/mL

2'-5'-oligoadenylate synthase 3, ELISA Kit - MBS760140 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/ml Range 0.78-50ng/ml

2'-5'-oligoadenylate synthase 3, ELISA Kit - MBS2884432 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.78-50 ng/mL

2, 5-OAS (2, 5-oligoadenylate synthetase), ELISA Kit - MBS7606307 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.281ng/ml Range 0.469-30ng/ml

2, 5-OAS (2, 5-oligoadenylate synthetase), ELISA Kit - MBS7606357 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/ml Range 0.781-50ng/ml

Human OAS3 / p100 ELISA Kit (Sandwich ELISA) - LS-F34102 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.469 Range 0.156-10 ng/ml

Search more