OAS3
| Gene Symbol | OAS3 |
|---|---|
| Entrez Gene | 4940 |
| Alt Symbol | p100, p100OAS |
| Species | Human |
| Gene Type | protein-coding |
| Description | 2'-5'-oligoadenylate synthetase 3, 100kDa |
| Other Description | (2-5')oligo(A) synthase 3|(2-5')oligo(A) synthetase 3|2'-5'-oligoadenylate synthase 3|2'-5'oligoadenylate synthetase p100|2-5A synthase 3|2-5A synthetase 3|p100 OAS |
| Swissprots | Q9Y6K5 Q9H3P5 Q2HJ14 |
| Accessions | CBI67637 CBI70412 CDI30182 EAW98024 EAW98025 Q9Y6K5 AB044545 BAB18647 AF063613 AAD28543 AK000608 AK292949 BAF85638 BC012015 BC113746 AAI13747 BG390192 BG765554 BM474470 BU558279 BU860096 W47620 XM_005253889 XP_005253946 NM_006187 NP_006178 |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}. |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Present at high level in placenta trophoblast. |
| Top Pathways | Hepatitis C, Measles, Influenza A, Herpes simplex infection |
OAS3 CRISPR/Cas9 KO Plasmid (h) - sc-405992 from Santa Cruz Biotechnology
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OAS3 HDR Plasmid (h) - sc-405992-HDR from Santa Cruz Biotechnology
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OAS3 Double Nickase Plasmid (h) - sc-405992-NIC from Santa Cruz Biotechnology
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OAS3 Double Nickase Plasmid (h2) - sc-405992-NIC-2 from Santa Cruz Biotechnology
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OAS3 CRISPR Activation Plasmid (h) - sc-405992-ACT from Santa Cruz Biotechnology
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OAS3 CRISPR Activation Plasmid (h2) - sc-405992-ACT-2 from Santa Cruz Biotechnology
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OAS3 Lentiviral Activation Particles (h) - sc-405992-LAC from Santa Cruz Biotechnology
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OAS3 Lentiviral Activation Particles (h2) - sc-405992-LAC-2 from Santa Cruz Biotechnology
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OAS3 siRNA (h) - sc-61245 from Santa Cruz Biotechnology
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OAS3 shRNA Plasmid (h) - sc-61245-SH from Santa Cruz Biotechnology
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OAS3 shRNA (h) Lentiviral Particles - sc-61245-V from Santa Cruz Biotechnology
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OAS3 RNAi - H00004940-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15665 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15665 from Sigma-Aldrich
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OAS3 siRNA (Human) - CRH3284 from Cohesion Biosciences
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shRNA set against Human OAS3 (NM_006187.2) - SHH356988 from Creative biogene
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shRNA set against Human OAS3(NM_006187.2) - SHR028950 from Creative biogene
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Human OAS3 siRNA - orb263786 from Biorbyt
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OAS3 shRNA Plasmid (Human) - CHH3284 from Cohesion Biosciences
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OAS3 miRNA 3'UTR clone - MiUTR1H-07021 from Creative biogene
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