| Gene Symbol | UBASH3B |
|---|---|
| Entrez Gene | 84959 |
| Alt Symbol | STS-1, STS1, TULA-2, TULA2, p70 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin associated and SH3 domain containing B |
| Other Description | Cbl-interacting protein Sts-1|SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate|T-cell ubiquitin ligand 2|cbl-interacting protein p70|nm23-phosphorylated unknown substrate|suppressor of T-cell receptor signaling 1|tyrosine-protein phosphatase STS1/TULA2|ubiquitin-associated and SH3 domain-containing protein B |
| Swissprots | Q53GT5 Q8NBV7 Q96IG9 Q53GT8 Q96NZ2 Q8TF42 |
| Accessions | CAF86506 CBX47427 EAW67531 Q8TF42 AB075839 BAB85545 AF425252 AAL16953 AK075203 BAC11468 AK092011 AK222843 BAD96563 AK222846 BAD96566 AL833092 BC007541 AAH07541 CA313832 CR741636 DA197468 XM_005271712 XP_005271769 XM_011543041 XP_011541343 XM_011543042 XP_011541344 NM_032873 NP_116262 |
| Function | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}. |