Gene Symbol | UBASH3B |
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Entrez Gene | 84959 |
Alt Symbol | STS-1, STS1, TULA-2, TULA2, p70 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin associated and SH3 domain containing B |
Other Description | Cbl-interacting protein Sts-1|SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate|T-cell ubiquitin ligand 2|cbl-interacting protein p70|nm23-phosphorylated unknown substrate|suppressor of T-cell receptor signaling 1|tyrosine-protein phosphatase STS1/TULA2|ubiquitin-associated and SH3 domain-containing protein B |
Swissprots | Q53GT5 Q8NBV7 Q96IG9 Q53GT8 Q96NZ2 Q8TF42 |
Accessions | CAF86506 CBX47427 EAW67531 Q8TF42 AB075839 BAB85545 AF425252 AAL16953 AK075203 BAC11468 AK092011 AK222843 BAD96563 AK222846 BAD96566 AL833092 BC007541 AAH07541 CA313832 CR741636 DA197468 XM_005271712 XP_005271769 XM_011543041 XP_011541343 XM_011543042 XP_011541344 NM_032873 NP_116262 |
Function | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}. |
STS-1 CRISPR/Cas9 KO Plasmid (h) - sc-406878 from Santa Cruz Biotechnology
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STS-1 HDR Plasmid (h) - sc-406878-HDR from Santa Cruz Biotechnology
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STS-1 Double Nickase Plasmid (h) - sc-406878-NIC from Santa Cruz Biotechnology
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STS-1 Double Nickase Plasmid (h2) - sc-406878-NIC-2 from Santa Cruz Biotechnology
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STS-1 CRISPR Activation Plasmid (h) - sc-406878-ACT from Santa Cruz Biotechnology
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STS-1 CRISPR Activation Plasmid (h2) - sc-406878-ACT-2 from Santa Cruz Biotechnology
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STS-1 Lentiviral Activation Particles (h) - sc-406878-LAC from Santa Cruz Biotechnology
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STS-1 Lentiviral Activation Particles (h2) - sc-406878-LAC-2 from Santa Cruz Biotechnology
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STS-1 siRNA (h) - sc-76596 from Santa Cruz Biotechnology
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STS-1 shRNA Plasmid (h) - sc-76596-SH from Santa Cruz Biotechnology
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STS-1 shRNA (h) Lentiviral Particles - sc-76596-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU008351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22349 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22349 from Sigma-Aldrich
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UBASH3B siRNA (Human) - CRJ3727 from Cohesion Biosciences
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UBASH3B - MBS828536 from MyBioSource
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shRNA set against Human UBASH3B (NM_032873.4) - SHH438784 from Creative biogene
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shRNA set against Human STS-1(NM_032873.4) - SHG144439 from Creative biogene
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Human UBASH3B siRNA - orb274228 from Biorbyt
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UBASH3B shRNA Plasmid (Human) - CHJ3727 from Cohesion Biosciences
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UBASH3B miRNA 3'UTR clone - MiUTR1H-10032 from Creative biogene
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