| Gene Symbol | HNRNPD |
|---|---|
| Entrez Gene | 3184 |
| Alt Symbol | AUF1, AUF1A, HNRPD, P37, hnRNPD0 |
| Species | Human |
| Gene Type | protein-coding |
| Description | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) |
| Other Description | ARE-binding protein AUFI, type A|heterogeneous nuclear ribonucleoprotein D0|hnRNP D0 |
| Swissprots | Q9UCE9 Q01858 Q14102 Q9UCE8 P07029 A8K9J2 Q14101 Q4W5A1 Q14103 Q14100 |
| Accessions | AAC23474 AAC23475 AAC23476 AAY40913 CBF67662 CBU92536 EAX05872 EAX05873 EAX05874 EAX05875 EAX05876 EAX05877 EAX05878 EAX05879 EAX05880 EAX05881 EAX05882 EAX05883 Q14103 AF039575 AAB96683 AK057836 AK292707 BAF85396 AK300149 BAG61935 AK303552 BAG64576 AL832723 BC002401 AAH02401 BC023977 AAH23977 BC026015 AAH26015 BF693760 BG180865 BG180941 BG325979 BM825808 BM832779 D55671 BAA09522 D55672 BAA09523 D55673 BAA09524 D55674 BAA09525 DQ892240 ABM83166 DQ895440 ABM86366 M94630 AAA35781 X03910 CAA27544 NM_001003810 NP_001003810 NM_002138 NP_002129 NM_031369 NP_112737 NM_031370 NP_112738 |
| Function | Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation o |
| Subcellular Location | Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally. |
HNRNPD cDNA (ANA11606) - ANA11606 from Aviva Systems Biology
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HNRNPD - MBS1275962 from MyBioSource
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Human HNRNPD cDNA clone(NM_031369.2) - CDFG005400 from Creative Biomart
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Human HNRNPD cDNA clone(NM_031369.2) - CDFG005401 from Creative Biomart
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Human HNRNPD cDNA clone(NM_031370.2) - CDFG005402 from Creative Biomart
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Human HNRNPD cDNA clone(NM_001003810.1) - CDFH008678 from Creative Biomart
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Human HNRNPD cDNA clone(NM_002138.3) - CDFH008679 from Creative Biomart
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Human HNRNPD ORF clone(NM_031370.2) - CDCR006552 from Creative Biomart
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Human HNRNPD ORF Clone(NM_002138.3) - CDCR282480 from Creative Biomart
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Human HNRNPD ORF Clone(NM_002138.3) - CDCR282481 from Creative Biomart
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Human HNRNPD ORF Clone(NM_031369.2) - CDCR311109 from Creative Biomart
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Human HNRNPD ORF Clone(NM_031369.2) - CDCR311110 from Creative Biomart
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Human HNRNPD ORF Clone(NM_031370.2) - CDCR311111 from Creative Biomart
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Human HNRNPD ORF Clone(NM_031370.2) - CDCR311112 from Creative Biomart
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Human HNRNPD ORF Clone(NM_001003810.1) - CDCR338999 from Creative Biomart
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Human HNRNPD ORF Clone(NM_001003810.1) - CDCR339000 from Creative Biomart
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Human HNRNPD ORF Clone(NM_002138.3) - CDCR282480 from Creative biogene
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Human HNRNPD ORF Clone(NM_031370.2) - CDCR311111 from Creative biogene
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Human HNRNPD ORF clone (NM_001003810.1) - CDCL117807 from Creative biogene
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Human HNRNPD ORF clone (NM_031369.2) - CDCL117809 from Creative biogene
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Human HNRNPD ORF Clone (BC023977) - CDCS406189 from Creative biogene
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Human HNRNPD cDNA Clone(NM_031369.2) - CDFG005400 from Creative biogene
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Human HNRNPD cDNA Clone(NM_031369.2) - CDFG005401 from Creative biogene
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Human HNRNPD cDNA Clone(NM_031370.2) - CDFG005402 from Creative biogene
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Human HNRNPD cDNA Clone(NM_001003810.1) - CDFH008678 from Creative biogene
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