HNRNPD

Gene Symbol	HNRNPD
Entrez Gene	3184
Alt Symbol	AUF1, AUF1A, HNRPD, P37, hnRNPD0
Species	Human
Gene Type	protein-coding
Description	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
Other Description	ARE-binding protein AUFI, type A|heterogeneous nuclear ribonucleoprotein D0|hnRNP D0
Swissprots	Q9UCE9 Q01858 Q14102 Q9UCE8 P07029 A8K9J2 Q14101 Q4W5A1 Q14103 Q14100
Accessions	AAC23474 AAC23475 AAC23476 AAY40913 CBF67662 CBU92536 EAX05872 EAX05873 EAX05874 EAX05875 EAX05876 EAX05877 EAX05878 EAX05879 EAX05880 EAX05881 EAX05882 EAX05883 Q14103 AF039575 AAB96683 AK057836 AK292707 BAF85396 AK300149 BAG61935 AK303552 BAG64576 AL832723 BC002401 AAH02401 BC023977 AAH23977 BC026015 AAH26015 BF693760 BG180865 BG180941 BG325979 BM825808 BM832779 D55671 BAA09522 D55672 BAA09523 D55673 BAA09524 D55674 BAA09525 DQ892240 ABM83166 DQ895440 ABM86366 M94630 AAA35781 X03910 CAA27544 NM_001003810 NP_001003810 NM_002138 NP_002129 NM_031369 NP_112737 NM_031370 NP_112738
Function	Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation o
Subcellular Location	Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® AUF1/hnRNP D siRNA I - 12763 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

hnRNP D0 CRISPR/Cas9 KO Plasmid (h) - sc-401911 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

hnRNP D0 HDR Plasmid (h) - sc-401911-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

hnRNP D0 Double Nickase Plasmid (h) - sc-401911-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

hnRNP D0 Double Nickase Plasmid (h2) - sc-401911-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

hnRNP D0 CRISPR Activation Plasmid (h) - sc-401911-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

hnRNP D0 CRISPR Activation Plasmid (h2) - sc-401911-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

hnRNP D0 Lentiviral Activation Particles (h) - sc-401911-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

hnRNP D0 Lentiviral Activation Particles (h2) - sc-401911-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

hnRNP D0 siRNA (h) - sc-37028 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

hnRNP D0 shRNA Plasmid (h) - sc-37028-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

hnRNP D0 shRNA (h) Lentiviral Particles - sc-37028-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

AUF1 RNAi - H00003184-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

AUF1 RNAi - H00003184-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU094941 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU115241 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10202 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10202 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06757 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06757

HNRNPD siRNA (Human) - CRH2175 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

AUF1 RNAi - H00003184-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

AUF1 RNAi - H00003184-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HNRNPD - MBS8208363 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human HNRNPD (NM_002138.3) - SHH313765 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human HNRPD(NM_002138.3) - SHH126893 from Creative biogene Category siRNA Species Reactivities Human

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