| Gene Symbol |
CYP4V2
|
| Entrez Gene |
285440
|
| Alt Symbol |
BCD, CYP4AH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 4, subfamily V, polypeptide 2
|
| Other Description |
cytochrome P450 4V2|docosahexaenoic acid omega-hydroxylase CYP4V2
|
| Swissprots |
Q6ZTM4 B7U6W2 Q6ZWL3
|
| Accessions |
ACK44069 EAX04624 Q6ZWL3 AA918796 AK022114 AK122600 BAC85487 AK126473 BAC86562 AK311390 AY358619 AAQ88982 AY422002 AAR31180 BC035933 BC038095 BC041839 AAH41839 BC048253 BC060857 AAH60857 BX648537 BX648730 JF432355 ADZ15572 XM_005262935 XP_005262992 XM_006714184 XP_006714247 NM_207352 NP_997235
|
| Function |
Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20- hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592). {ECO:0000269|PubMed:19661213, ECO:0000269|PubMed:22772592}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:22772592}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes. {ECO:0000269|PubMed:15042513, ECO:0000269|PubMed:22772592}.
|