CYP4V2

Gene Symbol CYP4V2
Entrez Gene 285440
Alt Symbol BCD, CYP4AH1
Species Human
Gene Type protein-coding
Description cytochrome P450, family 4, subfamily V, polypeptide 2
Other Description cytochrome P450 4V2|docosahexaenoic acid omega-hydroxylase CYP4V2
Swissprots Q6ZTM4 B7U6W2 Q6ZWL3
Accessions ACK44069 EAX04624 Q6ZWL3 AA918796 AK022114 AK122600 BAC85487 AK126473 BAC86562 AK311390 AY358619 AAQ88982 AY422002 AAR31180 BC035933 BC038095 BC041839 AAH41839 BC048253 BC060857 AAH60857 BX648537 BX648730 JF432355 ADZ15572 XM_005262935 XP_005262992 XM_006714184 XP_006714247 NM_207352 NP_997235
Function Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20- hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592). {ECO:0000269|PubMed:19661213, ECO:0000269|PubMed:22772592}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:22772592}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes. {ECO:0000269|PubMed:15042513, ECO:0000269|PubMed:22772592}.

Human CYP4V2 full length protein - ab166203 from Abcam

Category Protein
Source Wheat germ
Species Human
ab166203 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CYP4V2 Antibody Blocking Peptide - LS-E5115 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CYP4V2 Antibody Blocking Peptide - LS-E20278 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human CYP4V2 Protein - H00285440-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CYP4V2-Antibody-C-term-Blocking-Peptide - BP17539b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CYP4V2 Blocking Peptide - 33R-8274 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

CYP4V2 - H00285440-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CYP4V2 - H00285440-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

CYP4V2 fusion protein - ag4952 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

CYP4V2 Protein - abx163761 from Abbexa

Category Protein
Species Human

CYP4V2 Recombinant Protein Antigen - NBP1-85361PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CYP4V2 Peptide, Human - M34GP03984H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Cytochrome P450 4V2 (CYP4V2), Recombinant Protein - MBS7013463 from MyBioSource

Category Protein
Prices $1,320.00, $2,310.00, $3,515.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Human

Cytochrome P450 4V2 (CYP4V2), Recombinant Protein - MBS7013465 from MyBioSource

Category Protein
Prices $1,320.00, $2,310.00, $3,515.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Orangutan
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