CYP4V2

Gene Symbol CYP4V2
Entrez Gene 285440
Alt Symbol BCD, CYP4AH1
Species Human
Gene Type protein-coding
Description cytochrome P450, family 4, subfamily V, polypeptide 2
Other Description cytochrome P450 4V2|docosahexaenoic acid omega-hydroxylase CYP4V2
Swissprots Q6ZTM4 B7U6W2 Q6ZWL3
Accessions ACK44069 EAX04624 Q6ZWL3 AA918796 AK022114 AK122600 BAC85487 AK126473 BAC86562 AK311390 AY358619 AAQ88982 AY422002 AAR31180 BC035933 BC038095 BC041839 AAH41839 BC048253 BC060857 AAH60857 BX648537 BX648730 JF432355 ADZ15572 XM_005262935 XP_005262992 XM_006714184 XP_006714247 NM_207352 NP_997235
Function Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20- hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592). {ECO:0000269|PubMed:19661213, ECO:0000269|PubMed:22772592}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:22772592}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes. {ECO:0000269|PubMed:15042513, ECO:0000269|PubMed:22772592}.

CYP4V2 (M29-P3B10) - sc-101386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CYP4V2 (M29-P3B10): sc-101386. Western blot analysis of CYP4V2 expression in human liver microsomes.

CYP4V2 (F-15) - sc-104182 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CYP4V2 (T-14) - sc-104183 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CYP4V2 (T-14): sc-104183. Western blot analysis of CYP4V2 expression in ARPE-19 (A) and NIH/3T3 (B) whole cell lysates.

Anti-CYP4V2 antibody - ab90271 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CYP4V2 antibody (ab90271) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CYP4V2 antibody - ab69392 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CYP4V2 antibody (ab69392) at 1/500 dilutionLane 1 : CYP4V2 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-CYP4V2 antibody - C-terminal - ab173150 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CYP4V2 antibody - C-terminal (ab173150) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-CYP4V2 Antibody (aa495-525, AP) - LS-C255807 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4V2 Antibody (aa495-525, Biotin) - LS-C255808 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4V2 Antibody (aa431-480) - LS-C111771 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYP4V2 antibody LS-C111771 Western blot of Jurkat lysate.

Anti-CYP4V2 Antibody (aa495-525, FITC) - LS-C255809 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4V2 Antibody (aa495-525, Azide-free, HRP) - LS-C255810 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4V2 Antibody (aa495-525, PE) - LS-C255811 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4V2 Antibody - LS-C307157 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-CYP4V2 Antibody - LS-C311081 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4V2 Antibody (aa495-525) - LS-C159432 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYP4V2 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The CYP4V2 antibody detected the CYP4V2 protein (arrow).

Anti-CYP4V2 Antibody (aa495-525) - LS-C320720 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4V2 Antibody (aa495-525, APC) - LS-C255806 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

CYP4V2 Antibody - NBP1-60084 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYP4V2 Antibody [NBP1-60084] - Jurkat cell lysate, concentration 0.2-1 ug/ml.

CYP4V2 Antibody - NBP1-85361 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYP4V2 Antibody [NBP1-85361] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: SK-MEL-30

CYP4V2 Antibody - H00285440-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

CYP4V2 Antibody - H00285440-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CYP4V2 antibody produced in rabbit - SAB2103886 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP4V2, antibody produced in rabbit: <B>Cat. No. SAB2103886</B>: Immunoblotting analysis of CYP4V2 in Jurkat cell lysate with CYP4V2 anitbody at 1 μg/mL.

Anti-CYP4V2 antibody produced in rabbit - SAB1410565 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP4V2: <B>Cat. No. SAB1410565</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~60.7 kDa using human kidney lysate.

Anti-CYP4V2 antibody produced in rabbit - HPA029122 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CYP4V2: <B>Cat. No. HPA029122</B>: Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

Anti-CYP4V2 antibody produced in mouse - SAB1400858 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-CYP4V2, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400858</B>: Antibody concentration: 1.0 ~ 5.0 μg/mL. Specific band of ~60.7 kDa using human liver lysate.
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