CYP4V2

Gene Symbol CYP4V2
Entrez Gene 285440
Alt Symbol BCD, CYP4AH1
Species Human
Gene Type protein-coding
Description cytochrome P450, family 4, subfamily V, polypeptide 2
Other Description cytochrome P450 4V2|docosahexaenoic acid omega-hydroxylase CYP4V2
Swissprots Q6ZTM4 B7U6W2 Q6ZWL3
Accessions ACK44069 EAX04624 Q6ZWL3 AA918796 AK022114 AK122600 BAC85487 AK126473 BAC86562 AK311390 AY358619 AAQ88982 AY422002 AAR31180 BC035933 BC038095 BC041839 AAH41839 BC048253 BC060857 AAH60857 BX648537 BX648730 JF432355 ADZ15572 XM_005262935 XP_005262992 XM_006714184 XP_006714247 NM_207352 NP_997235
Function Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20- hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592). {ECO:0000269|PubMed:19661213, ECO:0000269|PubMed:22772592}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:22772592}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes. {ECO:0000269|PubMed:15042513, ECO:0000269|PubMed:22772592}.

CYP4V2 CRISPR/Cas9 KO Plasmid (h) - sc-409088 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4V2 HDR Plasmid (h) - sc-409088-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4V2 Double Nickase Plasmid (h) - sc-409088-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4V2 Double Nickase Plasmid (h2) - sc-409088-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4V2 CRISPR Activation Plasmid (h) - sc-409088-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4V2 CRISPR Activation Plasmid (h2) - sc-409088-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4V2 Lentiviral Activation Particles (h) - sc-409088-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4V2 Lentiviral Activation Particles (h2) - sc-409088-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4V2 siRNA (h) - sc-89024 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP4V2 shRNA Plasmid (h) - sc-89024-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP4V2 shRNA (h) Lentiviral Particles - sc-89024-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU094191 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU016131 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6895 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6895 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11857 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11857

CYP4V2 siRNA (Human) - CRJ7098 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP4V2 RNAi - H00285440-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CYP4V2 - MBS8227949 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CYP4V2 (NM_207352.3) - SHH273741 from Creative biogene

Category siRNA
Species Reactivities Human

Human CYP4V2 siRNA - orb277599 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP4V2 shRNA Plasmid (Human) - CHJ7098 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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