MRAP2

Gene Symbol MRAP2
Entrez Gene 112609
Alt Symbol BMIQ18, C6orf117, bA51G5.2
Species Human
Gene Type protein-coding
Description melanocortin 2 receptor accessory protein 2
Other Description MC2R accessory protein 2|melanocortin-2 receptor accessory protein 2
Swissprots A8K9M1 Q8IXM9 Q96G30 Q8N2D1
Accessions EAW48646 Q96G30 AJ420596 AK090775 BAC03517 AK292736 BAF85425 AK307078 BC010003 AAH10003 BC039855 AAH39855 BU629097 HQ447616 ADQ32102 XM_005248644 XP_005248701 XM_005248645 XP_005248702 XM_011535400 XP_011533702 XM_011535401 XP_011533703 XM_011535402 XP_011533704 XM_011535403 XP_011533705 NM_138409 NP_612418
Function Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. {ECO:0000250, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000269|PubMed:20371771}.
Tissue Specificity Expressed in the adrenal gland and brain. Not expressed in other tissues. {ECO:0000269|PubMed:19329486}.

MRAP2-Over-expression-Lysate - LY15849a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag MRAP2 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MRAP2 gene‘

MRAP2 overexpression lysate - LY408667 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

MRAP2 293 Cell Lysate - 404725 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

MRAP2 Overexpression Lysate (Native) - NBL1-08508 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MRAP2 Overexpression Lysate (Adult Normal) [NBL1-08508] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MRAP2.

MRAP2 Over-expression Lysate Product - GWB-B004D9 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

MRAP2 Overexpression Lysate (Denatured) - H00112609-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human MRAP2 Knockdown Stable Cell Line - CSC-DC009698 from Creative biogene

Category Cell Line
Species Human
Search more