| Gene Symbol |
MRAP2
|
| Entrez Gene |
112609
|
| Alt Symbol |
BMIQ18, C6orf117, bA51G5.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
melanocortin 2 receptor accessory protein 2
|
| Other Description |
MC2R accessory protein 2|melanocortin-2 receptor accessory protein 2
|
| Swissprots |
A8K9M1 Q8IXM9 Q96G30 Q8N2D1
|
| Accessions |
EAW48646 Q96G30 AJ420596 AK090775 BAC03517 AK292736 BAF85425 AK307078 BC010003 AAH10003 BC039855 AAH39855 BU629097 HQ447616 ADQ32102 XM_005248644 XP_005248701 XM_005248645 XP_005248702 XM_011535400 XP_011533702 XM_011535401 XP_011533703 XM_011535402 XP_011533704 XM_011535403 XP_011533705 NM_138409 NP_612418
|
| Function |
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. {ECO:0000250, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000269|PubMed:20371771}.
|
| Tissue Specificity |
Expressed in the adrenal gland and brain. Not expressed in other tissues. {ECO:0000269|PubMed:19329486}.
|