MRAP2

Gene Symbol MRAP2
Entrez Gene 112609
Alt Symbol BMIQ18, C6orf117, bA51G5.2
Species Human
Gene Type protein-coding
Description melanocortin 2 receptor accessory protein 2
Other Description MC2R accessory protein 2|melanocortin-2 receptor accessory protein 2
Swissprots A8K9M1 Q8IXM9 Q96G30 Q8N2D1
Accessions EAW48646 Q96G30 AJ420596 AK090775 BAC03517 AK292736 BAF85425 AK307078 BC010003 AAH10003 BC039855 AAH39855 BU629097 HQ447616 ADQ32102 XM_005248644 XP_005248701 XM_005248645 XP_005248702 XM_011535400 XP_011533702 XM_011535401 XP_011533703 XM_011535402 XP_011533704 XM_011535403 XP_011533705 NM_138409 NP_612418
Function Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. {ECO:0000250, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000269|PubMed:20371771}.
Tissue Specificity Expressed in the adrenal gland and brain. Not expressed in other tissues. {ECO:0000269|PubMed:19329486}.

MRAP2 CRISPR/Cas9 KO Plasmid (h) - sc-414003 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRAP2 HDR Plasmid (h) - sc-414003-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRAP2 Double Nickase Plasmid (h) - sc-414003-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRAP2 Double Nickase Plasmid (h2) - sc-414003-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRAP2 CRISPR Activation Plasmid (h) - sc-414003-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRAP2 CRISPR Activation Plasmid (h2) - sc-414003-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRAP2 Lentiviral Activation Particles (h) - sc-414003-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRAP2 Lentiviral Activation Particles (h2) - sc-414003-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRAP2 siRNA (h) - sc-95279 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRAP2 shRNA Plasmid (h) - sc-95279-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRAP2 shRNA (h) Lentiviral Particles - sc-95279-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU048721 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14523 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14523 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09447 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09447

MRAP2 siRNA (Human) - CRJ4281 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MRAP2 (NM_138409.2) - SHH344178 from Creative biogene

Category siRNA
Species Reactivities Human

Human MRAP2 siRNA - orb274782 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MRAP2 shRNA Plasmid (Human) - CHJ4281 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MRAP2 miRNA 3'UTR clone - MiUTR1H-01438 from Creative biogene

Species Reactivities Human
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