| Gene Symbol |
ANKRD2
|
| Entrez Gene |
26287
|
| Alt Symbol |
ARPP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ankyrin repeat domain 2 (stretch responsive muscle)
|
| Other Description |
ankyrin repeat domain-containing protein 2|skeletal muscle ankyrin repeat protein
|
| Swissprots |
Q70EZ9 Q3B778 Q96MG0 Q5T456 Q8WUD7 Q9GZV1 Q9NQC9
|
| Accessions |
CAC19411 EAW49916 EAW49917 Q9GZV1 AB058599 BAB60958 AJ249975 CAB99416 AJ304805 CAC19412 AJ346356 AJ583444 CAE47432 AK056990 AK314763 BAG37301 BC020817 AAH20817 BC107759 AAI07760 DA893829 NM_001129981 NP_001123453 NM_001291218 NP_001278147 NM_001291219 NP_001278148 NM_020349 NP_065082
|
| Function |
Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}.
|
| Subcellular Location |
Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
|
| Tissue Specificity |
Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level). {ECO:0000269|PubMed:11444853, ECO:0000269|PubMed:11453652}.
|
![Western Blot: ANKRD2 Overexpression Lysate (Adult Normal) [NBL1-07535] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ANKRD2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7328_ANKRD2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07535-img0002.jpg)