Gene Symbol | ANKRD2 |
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Entrez Gene | 26287 |
Alt Symbol | ARPP |
Species | Human |
Gene Type | protein-coding |
Description | ankyrin repeat domain 2 (stretch responsive muscle) |
Other Description | ankyrin repeat domain-containing protein 2|skeletal muscle ankyrin repeat protein |
Swissprots | Q70EZ9 Q3B778 Q96MG0 Q5T456 Q8WUD7 Q9GZV1 Q9NQC9 |
Accessions | CAC19411 EAW49916 EAW49917 Q9GZV1 AB058599 BAB60958 AJ249975 CAB99416 AJ304805 CAC19412 AJ346356 AJ583444 CAE47432 AK056990 AK314763 BAG37301 BC020817 AAH20817 BC107759 AAI07760 DA893829 NM_001129981 NP_001123453 NM_001291218 NP_001278147 NM_001291219 NP_001278148 NM_020349 NP_065082 |
Function | Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}. |
Subcellular Location | Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress. |
Tissue Specificity | Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level). {ECO:0000269|PubMed:11444853, ECO:0000269|PubMed:11453652}. |
ANKRD2 CRISPR/Cas9 KO Plasmid (h) - sc-409884 from Santa Cruz Biotechnology
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ANKRD2 HDR Plasmid (h) - sc-409884-HDR from Santa Cruz Biotechnology
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ANKRD2 Double Nickase Plasmid (h) - sc-409884-NIC from Santa Cruz Biotechnology
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ANKRD2 Double Nickase Plasmid (h2) - sc-409884-NIC-2 from Santa Cruz Biotechnology
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ANKRD2 CRISPR Activation Plasmid (h) - sc-409884-ACT from Santa Cruz Biotechnology
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ANKRD2 CRISPR Activation Plasmid (h2) - sc-409884-ACT-2 from Santa Cruz Biotechnology
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ANKRD2 Lentiviral Activation Particles (h) - sc-409884-LAC from Santa Cruz Biotechnology
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ANKRD2 Lentiviral Activation Particles (h2) - sc-409884-LAC-2 from Santa Cruz Biotechnology
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ANKRD2 siRNA (h) - sc-90498 from Santa Cruz Biotechnology
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ANKRD2 shRNA Plasmid (h) - sc-90498-SH from Santa Cruz Biotechnology
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ANKRD2 shRNA (h) Lentiviral Particles - sc-90498-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU074651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3183 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3183 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00315 from Sigma-Aldrich
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ANKRD2 siRNA (Human) - CRH8807 from Cohesion Biosciences
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ANKRD2 - MBS826949 from MyBioSource
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shRNA set against Human ANKRD2 (NM_020349.2) - SHH236662 from Creative biogene
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shRNA set against Human ANKRD2(NM_020349.2) - SHG059743 from Creative biogene
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ANKRD2 shRNA Plasmid (Human) - CHH8807 from Cohesion Biosciences
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ANKRD2 miRNA 3'UTR clone - MiUTR1H-00385 from Creative biogene
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ANKRD2 miRNA 3'UTR clone - MiUTR3H-11435 from Creative biogene
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