| Gene Symbol | ANKRD2 |
|---|---|
| Entrez Gene | 26287 |
| Alt Symbol | ARPP |
| Species | Human |
| Gene Type | protein-coding |
| Description | ankyrin repeat domain 2 (stretch responsive muscle) |
| Other Description | ankyrin repeat domain-containing protein 2|skeletal muscle ankyrin repeat protein |
| Swissprots | Q70EZ9 Q3B778 Q96MG0 Q5T456 Q8WUD7 Q9GZV1 Q9NQC9 |
| Accessions | CAC19411 EAW49916 EAW49917 Q9GZV1 AB058599 BAB60958 AJ249975 CAB99416 AJ304805 CAC19412 AJ346356 AJ583444 CAE47432 AK056990 AK314763 BAG37301 BC020817 AAH20817 BC107759 AAI07760 DA893829 NM_001129981 NP_001123453 NM_001291218 NP_001278147 NM_001291219 NP_001278148 NM_020349 NP_065082 |
| Function | Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}. |
| Subcellular Location | Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress. |
| Tissue Specificity | Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level). {ECO:0000269|PubMed:11444853, ECO:0000269|PubMed:11453652}. |
Human ANKRD2 cDNA clone(NM_020349.2) - CDFG002620 from Creative Biomart
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Human ANKRD2 cDNA clone(NM_020349.2) - CDFG002622 from Creative Biomart
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Human ANKRD2 cDNA clone(NM_001129981.1) - CDFH000805 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_001129981.1) - CDCL153853 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_001129981.1) - CDCL153854 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_020349.2) - CDCL153855 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_001129981.1) - CDCL153856 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_020349.2) - CDCR305222 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_020349.2) - CDCR305223 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_020349.2) - CDCR305224 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_001129981.1) - CDCR349166 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_001129981.1) - CDCR349304 from Creative Biomart
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Human ANKRD2 ORF Clone(NM_020349.2) - CDCR305222 from Creative biogene
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Human ANKRD2 ORF clone (NM_001129981.1) - CDCR027780 from Creative biogene
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Human ANKRD2 cDNA Clone(NM_020349.2) - CDFG002620 from Creative biogene
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Human ANKRD2 cDNA Clone(NM_020349.2) - CDFG002622 from Creative biogene
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Human ANKRD2 cDNA Clone(NM_001129981.1) - CDFH000805 from Creative biogene
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