| Gene Symbol |
USP9Y
|
| Entrez Gene |
8287
|
| Alt Symbol |
DFFRY, SPGFY2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 9, Y-linked
|
| Other Description |
deubiquitinating enzyme FAF-Y|fat facets protein-related, Y-linked|probable ubiquitin carboxyl-terminal hydrolase FAF-Y|ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)|ubiquitin thioesterase FAF-Y|ubiquitin thiolesterase FAF-Y|ubiquitin-specific processing protease FAF-Y|ubiquitin-specific protease 9, Y chromosome|ubiquitin-specific-processing protease FAF-Y
|
| Swissprots |
O00507 O14601
|
| Accessions |
CCQ43269 EAW91607 EAW91608 O00507 AF000986 AAC51833 AK057605 BC156544 AAI56545 BI754571 CK823170 DQ151535 ABA28747 Y13618 CAA73940 Y13619 CAA73941 XM_011531469 XP_011529771 XM_011531470 XP_011529772 NM_004654 NP_004645
|
| Function |
May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re- empowers its competence to mediate TGF-beta signaling (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed in embryonic and adult tissues.
|