Gene Symbol | USP9Y |
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Entrez Gene | 8287 |
Alt Symbol | DFFRY, SPGFY2 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 9, Y-linked |
Other Description | deubiquitinating enzyme FAF-Y|fat facets protein-related, Y-linked|probable ubiquitin carboxyl-terminal hydrolase FAF-Y|ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)|ubiquitin thioesterase FAF-Y|ubiquitin thiolesterase FAF-Y|ubiquitin-specific processing protease FAF-Y|ubiquitin-specific protease 9, Y chromosome|ubiquitin-specific-processing protease FAF-Y |
Swissprots | O00507 O14601 |
Accessions | CCQ43269 EAW91607 EAW91608 O00507 AF000986 AAC51833 AK057605 BC156544 AAI56545 BI754571 CK823170 DQ151535 ABA28747 Y13618 CAA73940 Y13619 CAA73941 XM_011531469 XP_011529771 XM_011531470 XP_011529772 NM_004654 NP_004645 |
Function | May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re- empowers its competence to mediate TGF-beta signaling (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Widely expressed in embryonic and adult tissues. |
Anti-USP9Y antibody - ab56471 from Abcam
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Anti-USP9Y antibody [EPR13966] - ab181842 from Abcam
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Anti-USP9Y Antibody (clone 2D3) - LS-C198543 from LifeSpan Bioscience
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Anti-USP9Y Antibody (C-Terminus) - LS-C116831 from LifeSpan Bioscience
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USP9Y Antibody - NBP1-79749 from Novus Biologicals
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USP9Y Antibody (2D3) - H00008287-M05 from Novus Biologicals
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Monoclonal Anti-USP9Y antibody produced in mouse - WH0008287M5 from Sigma-Aldrich
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Anti-USP9Y antibody produced in rabbit - SAB2107378 from Sigma-Aldrich
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USP9Y antibody - C-terminal region (ARP59337_P050) - ARP59337_P050 from Aviva Systems Biology
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USP9Y-Antibody-monoclonal-M05 - AT4498a from Abgent, a WuXi AppTec company
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USP9Y antibody - 70R-9745 from Fitzgerald
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USP9Y antibody - H00008287-M05 from Acris Antibodies
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USP9Y, Monoclonal Antibody - MBS6012955 from MyBioSource
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USP9Y Antibody - GWB-MV572E from Genway Biotech
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Anti-USP9Y monoclonal antibody, clone FQS24077 - DCABH-7351 from Creative Diagnostics
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Anti-ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila) - 08A008287 from MP Biomedicals
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USP9Y, Polyclonal Antibody - MBS839459 from MyBioSource
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USP9Y antibody - TA342578 from Acris Antibodies
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Anti-USP9Y monoclonal antibody, clone 3E4 - CABT-BL5956 from Creative Diagnostics
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Recombinant Mouse anti-Human USP9Y Monoclonal antibody (EML902) - MOB-2187CT from Creative Biolabs
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Anti-USP9Y Antibody A06925 - A06925 from Boster Bio
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Hi-Affi™ Recombinant Rabbit Anti-USP9Y Monoclonal Antibody (DS3814AB) - MOR-3814 from Creative Biolabs
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USP9Y antibody - C-terminal region : Biotin (ARP59337_P050-Biotin) - ARP59337_P050-Biotin from Aviva Systems Biology
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USP9Y antibody - C-terminal region : FITC (ARP59337_P050-FITC) - ARP59337_P050-FITC from Aviva Systems Biology
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USP9Y antibody - C-terminal region : HRP (ARP59337_P050-HRP) - ARP59337_P050-HRP from Aviva Systems Biology
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