| Gene Symbol |
ADPRHL2
|
| Entrez Gene |
54936
|
| Alt Symbol |
ARH3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADP-ribosylhydrolase like 2
|
| Other Description |
ADP-ribosylhydrolase 3|[Protein ADP-ribosylarginine] hydrolase-like protein 2|poly(ADP-ribose) glycohydrolase ARH3|protein ADP-ribosylarginine hydrolase-like protein 2
|
| Swissprots |
Q9NX46 Q6IAB8 Q9BY47 Q53G94
|
| Accessions |
CAC85940 EAX07389 EAX07390 Q9NX46 AF212236 AAK14922 AJ427295 CAD20316 AK000453 BAA91174 AK223037 BAD96757 AK295283 BAG58267 AK316349 BAH14720 BC014169 AAH14169 CR457237 CAG33518 DC365461 XM_011541636 XP_011539938 NM_017825 NP_060295
|
| Function |
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. {ECO:0000269|PubMed:16278211}.
|
| Subcellular Location |
Cytoplasm. Mitochondrion matrix. Nucleus.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:16278211}.
|