Gene Symbol | ADPRHL2 |
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Entrez Gene | 54936 |
Alt Symbol | ARH3 |
Species | Human |
Gene Type | protein-coding |
Description | ADP-ribosylhydrolase like 2 |
Other Description | ADP-ribosylhydrolase 3|[Protein ADP-ribosylarginine] hydrolase-like protein 2|poly(ADP-ribose) glycohydrolase ARH3|protein ADP-ribosylarginine hydrolase-like protein 2 |
Swissprots | Q9NX46 Q6IAB8 Q9BY47 Q53G94 |
Accessions | CAC85940 EAX07389 EAX07390 Q9NX46 AF212236 AAK14922 AJ427295 CAD20316 AK000453 BAA91174 AK223037 BAD96757 AK295283 BAG58267 AK316349 BAH14720 BC014169 AAH14169 CR457237 CAG33518 DC365461 XM_011541636 XP_011539938 NM_017825 NP_060295 |
Function | Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. {ECO:0000269|PubMed:16278211}. |
Subcellular Location | Cytoplasm. Mitochondrion matrix. Nucleus. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:16278211}. |
ARH3 CRISPR/Cas9 KO Plasmid (h) - sc-407965 from Santa Cruz Biotechnology
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ARH3 HDR Plasmid (h) - sc-407965-HDR from Santa Cruz Biotechnology
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ARH3 Double Nickase Plasmid (h) - sc-407965-NIC from Santa Cruz Biotechnology
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ARH3 Double Nickase Plasmid (h2) - sc-407965-NIC-2 from Santa Cruz Biotechnology
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ARH3 CRISPR Activation Plasmid (h) - sc-407965-ACT from Santa Cruz Biotechnology
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ARH3 CRISPR Activation Plasmid (h2) - sc-407965-ACT-2 from Santa Cruz Biotechnology
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ARH3 Lentiviral Activation Particles (h) - sc-407965-LAC from Santa Cruz Biotechnology
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ARH3 Lentiviral Activation Particles (h2) - sc-407965-LAC-2 from Santa Cruz Biotechnology
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ARH3 siRNA (h) - sc-78611 from Santa Cruz Biotechnology
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ARH3 shRNA Plasmid (h) - sc-78611-SH from Santa Cruz Biotechnology
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ARH3 shRNA (h) Lentiviral Particles - sc-78611-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU062241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2897 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2897 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04842 from Sigma-Aldrich
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ADPRHL2 siRNA (Human) - CRJ0339 from Cohesion Biosciences
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ADPRHL2 - MBS8217822 from MyBioSource
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shRNA set against Human ADPRHL2 (NM_017825.2) - SHH232658 from Creative biogene
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ADPRHL2 shRNA Plasmid (Human) - CHJ0339 from Cohesion Biosciences
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ADPRHL2 miRNA 3'UTR clone - MiUTR3H-11358 from Creative biogene
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