Gene Symbol | ADPRHL2 |
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Entrez Gene | 54936 |
Alt Symbol | ARH3 |
Species | Human |
Gene Type | protein-coding |
Description | ADP-ribosylhydrolase like 2 |
Other Description | ADP-ribosylhydrolase 3|[Protein ADP-ribosylarginine] hydrolase-like protein 2|poly(ADP-ribose) glycohydrolase ARH3|protein ADP-ribosylarginine hydrolase-like protein 2 |
Swissprots | Q9NX46 Q6IAB8 Q9BY47 Q53G94 |
Accessions | CAC85940 EAX07389 EAX07390 Q9NX46 AF212236 AAK14922 AJ427295 CAD20316 AK000453 BAA91174 AK223037 BAD96757 AK295283 BAG58267 AK316349 BAH14720 BC014169 AAH14169 CR457237 CAG33518 DC365461 XM_011541636 XP_011539938 NM_017825 NP_060295 |
Function | Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. {ECO:0000269|PubMed:16278211}. |
Subcellular Location | Cytoplasm. Mitochondrion matrix. Nucleus. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:16278211}. |
Human ARH3 full length protein - ab130045 from Abcam
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Human ARH3 full length protein - ab157083 from Abcam
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ADPRHL2 Antibody Blocking Peptide - LS-E10281 from LifeSpan Bioscience
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ADPRHL2 Antibody Blocking Peptide - LS-E24145 from LifeSpan Bioscience
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ADPRHL2 Recombinant Protein - H00054936-P01 from Novus Biologicals
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Recombinant Human ADPRHL2 Protein - NBP1-98877 from Novus Biologicals
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ADPRHL2-Antibody-N-term-Blocking-Peptide - BP9723a from Abgent, a WuXi AppTec company
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Human ADPRHL2 protein - orb167859 from Biorbyt
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ADPRHL2 protein (His tag) - 80R-2408 from Fitzgerald
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ADPRHL2 / ARH3 (1-363, His-tag) - AR50489PU-N from Acris Antibodies
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ADPRHL2 / ARH3 (1-363, His-tag) - AR50489PU-S from Acris Antibodies
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ADPRHL2 / ARH3 - H00054936-P01-10 from Acris Antibodies
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ADPRHL2 / ARH3 - H00054936-P01-25 from Acris Antibodies
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ADPRHL2, 1-363aa, Human, His-tag, E.coli - 01-P1665 from ARP American Research Products
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ADPRHL2 fusion protein - Ag9683 from Proteintech Group
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ADPRHL2 Human - ENPS-645 from NeoScientific
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Recombinant Human ADP-Ribosylhydrolase Like 2 Enzyme - BP002544-ENZ-638 from Syd Labs
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ADPRHL2, 1-363aa, Recombinant Protein - GWB-P0373I from Genway Biotech
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Recombinant Human ADP-Ribosylhydrolase Like 2, His-tagged - ADPRHL2-2524H from Creative Biomart
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Recombinant Human ADP-ribosylhydrolase Like 2, His-tagged - ADPRHL2-2065H from Creative Biomart
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Recombinant Human ADPRHL2, His-tagged - ADPRHL2-9440H from Creative Biomart
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Recombinant Human Poly(ADP-ribose) glycohydrolase ARH3(ADPRHL2) - CSB-YP868344HU CSB-EP868344HU CSB-BP868344HU CSB-MP868344HU from Cusabio
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ADPRHL2, 1-363aa, Human, His tag, E.coli - ATGP1665 from ATGen
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ADP-Ribosylhydrolase Like 2 - MBS144601 from MyBioSource
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ADPRHL2 - MBS204609 from MyBioSource
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