| Gene Symbol |
SRPK2
|
| Entrez Gene |
6733
|
| Alt Symbol |
SFRSK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SRSF protein kinase 2
|
| Other Description |
SFRS protein kinase 2|SR protein kinase 2|SR-protein-specific kinase 2|serine kinase SRPK2|serine/arginine-rich protein-specific kinase 2|serine/arginine-rich splicing factor kinase 2|serine/threonine-protein kinase SRPK2
|
| Swissprots |
Q6V1X2 O75220 P78362 O75221 Q8IYQ3 Q6NUL0 A8MVX2
|
| Accessions |
AAC29140 AAC29141 AAS00352 EAW83359 EAW83360 EAW83361 P78362 AK092977 AK093420 AW086157 AY354201 AAQ63886 BC035214 AAH35214 BC068547 AAH68547 BI918658 BM805927 BU632662 CR746049 DA592321 DQ891337 ABM82263 DQ894519 ABM85445 HY031357 U88666 AAC05299 XM_005250549 XP_005250606 XM_005250550 XP_005250607 XM_005250551 XP_005250608 XM_006716098 XP_006716161 XM_011516531 XP_011514833 XM_011516532 XP_011514834 XM_011516533 XP_011514835 XM_011516534 XP_011514836 XM_011516535 XP_011514837 XM_011516536 XP_011514838 XM_011516537 XP_011514839 XM_011516538 XP_011514840 XM_011516539 XP_011514841 XM_011516540 XP_011514842 XR_927524 XR_927525 XR_927526 NM_001278273 NP_001265202 NM_182691 NP_872633 NM_182692 NP_872634
|
| Function |
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reduc
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.
|
| Tissue Specificity |
Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. {ECO:0000269|PubMed:9472028}.
|
![Western Blot: SRPK2 Overexpression Lysate (Adult Normal) [NBL1-16456] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SRPK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5886_SRPK2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16456-img0002.jpg)