SRPK2

Gene Symbol SRPK2
Entrez Gene 6733
Alt Symbol SFRSK2
Species Human
Gene Type protein-coding
Description SRSF protein kinase 2
Other Description SFRS protein kinase 2|SR protein kinase 2|SR-protein-specific kinase 2|serine kinase SRPK2|serine/arginine-rich protein-specific kinase 2|serine/arginine-rich splicing factor kinase 2|serine/threonine-protein kinase SRPK2
Swissprots Q6V1X2 O75220 P78362 O75221 Q8IYQ3 Q6NUL0 A8MVX2
Accessions AAC29140 AAC29141 AAS00352 EAW83359 EAW83360 EAW83361 P78362 AK092977 AK093420 AW086157 AY354201 AAQ63886 BC035214 AAH35214 BC068547 AAH68547 BI918658 BM805927 BU632662 CR746049 DA592321 DQ891337 ABM82263 DQ894519 ABM85445 HY031357 U88666 AAC05299 XM_005250549 XP_005250606 XM_005250550 XP_005250607 XM_005250551 XP_005250608 XM_006716098 XP_006716161 XM_011516531 XP_011514833 XM_011516532 XP_011514834 XM_011516533 XP_011514835 XM_011516534 XP_011514836 XM_011516535 XP_011514837 XM_011516536 XP_011514838 XM_011516537 XP_011514839 XM_011516538 XP_011514840 XM_011516539 XP_011514841 XM_011516540 XP_011514842 XR_927524 XR_927525 XR_927526 NM_001278273 NP_001265202 NM_182691 NP_872633 NM_182692 NP_872634
Function Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reduc
Subcellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.
Tissue Specificity Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. {ECO:0000269|PubMed:9472028}.

SRPK2 CRISPR/Cas9 KO Plasmid (h) - sc-403763 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRPK2 HDR Plasmid (h) - sc-403763-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRPK2 Double Nickase Plasmid (h) - sc-403763-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRPK2 Double Nickase Plasmid (h2) - sc-403763-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRPK2 CRISPR Activation Plasmid (h) - sc-403763-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRPK2 CRISPR Activation Plasmid (h2) - sc-403763-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRPK2 Lentiviral Activation Particles (h) - sc-403763-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRPK2 Lentiviral Activation Particles (h2) - sc-403763-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRPK2 siRNA (h) - sc-39237 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SRPK2 shRNA Plasmid (h) - sc-39237-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SRPK2 shRNA (h) Lentiviral Particles - sc-39237-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SRPK2 RNAi - H00006733-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SRPK2 RNAi - H00006733-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU090101 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2123 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2124 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2125 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN20585 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20585 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SRPK2 siRNA (Human) - CRH4600 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SRPK2 - MBS8229345 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SRPK2 (NM_182692.1) - SHH418000 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SRPK2(NM_182691.1) - SHL035058 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SRPK2(NM_182692.1) - SHL035118 from Creative biogene

Category siRNA
Species Reactivities Human

Human SRPK2 siRNA - orb265102 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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