SRPK2

Gene Symbol SRPK2
Entrez Gene 6733
Alt Symbol SFRSK2
Species Human
Gene Type protein-coding
Description SRSF protein kinase 2
Other Description SFRS protein kinase 2|SR protein kinase 2|SR-protein-specific kinase 2|serine kinase SRPK2|serine/arginine-rich protein-specific kinase 2|serine/arginine-rich splicing factor kinase 2|serine/threonine-protein kinase SRPK2
Swissprots Q6V1X2 O75220 P78362 O75221 Q8IYQ3 Q6NUL0 A8MVX2
Accessions AAC29140 AAC29141 AAS00352 EAW83359 EAW83360 EAW83361 P78362 AK092977 AK093420 AW086157 AY354201 AAQ63886 BC035214 AAH35214 BC068547 AAH68547 BI918658 BM805927 BU632662 CR746049 DA592321 DQ891337 ABM82263 DQ894519 ABM85445 HY031357 U88666 AAC05299 XM_005250549 XP_005250606 XM_005250550 XP_005250607 XM_005250551 XP_005250608 XM_006716098 XP_006716161 XM_011516531 XP_011514833 XM_011516532 XP_011514834 XM_011516533 XP_011514835 XM_011516534 XP_011514836 XM_011516535 XP_011514837 XM_011516536 XP_011514838 XM_011516537 XP_011514839 XM_011516538 XP_011514840 XM_011516539 XP_011514841 XM_011516540 XP_011514842 XR_927524 XR_927525 XR_927526 NM_001278273 NP_001265202 NM_182691 NP_872633 NM_182692 NP_872634
Function Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reduc
Subcellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.
Tissue Specificity Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. {ECO:0000269|PubMed:9472028}.

SRPK2 (A-5) - sc-390930 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRPK2 (A-5): sc-390930. Western blot analysis of SRPK2 expression in non-transfected: sc-117752 (A) and human SRPK2 transfected: sc-113878 (B) 293T whole cell lysates.

SRPK2 (H-81) - sc-292573 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SRPK2 (H-81): sc-292573. Western blot analysis of SRPK2 expression in mouse brain tissue extract (A) and MOLT-4 whole cell lysate (B).

SRPK2 (H-5) - sc-390534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRPK2 (H-5): sc-390534. Western blot analysis of SRPK2 expression in HeLa whole cell lysate.

SRPK2 (S-15) - sc-11307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SRPK2 (S-15): sc-11307. Western blot analysis of SRPK2 expression in non-transfected: sc-117752 (A) and human SRPK2 transfected: sc-113878 (B) 293T whole cell lysates.

SRPK2 (P-19) - sc-11308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SRPK2 (P-19): sc-11308. Western blot analysis of SRPK2 expression in non-transfected: sc-117752 (A) and mouse SRPK2 transfected: sc-123783 (B) 293T whole cell lysates.

SRPK2 (23) - sc-136078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
SRPK2 (23): sc-136078. Western blot analysis of SRPK2 expression in A-431 whole cell lysate.

Anti-SRPK2 antibody - ab67993 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SRPK2 antibody (ab67993) at 1/500 dilutionLane 1 : SRPK2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-SRPK2 antibody [EPR16366] - N-terminal - ab192238 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16366
Immunofluorescent analysis of Neuro-2a cells (4% Paraformaldehyde-fixed, 0.1% tritonX-100 permeabilized) labeling SRPK2 with ab192238 at 1/250 dilution (5.4 μg/mL) followed by Goat anti rabbit IgG (AlexaFluor® 488) (ab150077) secondary at 1/200 dilution and counter-stained with DAPI (blue).Negative controls: anti-SRPK2 at 1/250 dilution, Secondary ab (Goat anti mouse IgG (Alexa Fluor®594)) at 1/500 dilution.

Anti-SRPK2 Antibody (aa425-475) - LS-C286890 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SRPK2 by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-SRPK2 used at a dilution of 1:250.

Anti-SRPK2 Antibody (C-Terminus, AP) - LS-C220781 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRPK2 Antibody (C-Terminus, Biotin) - LS-C220782 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRPK2 Antibody (C-Terminus, APC) - LS-C220783 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRPK2 Antibody (C-Terminus, FITC) - LS-C220784 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRPK2 Antibody (C-Terminus, Azide-free, HRP) - LS-C220785 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRPK2 Antibody (C-Terminus, PE) - LS-C220786 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRPK2 Antibody (C-Terminus) - LS-C330673 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRPK2 Antibody (C-Terminus) - LS-C99919 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-SRPK2 Antibody (aa425-475) - LS-C289201 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SRPK2 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-SRPK2 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

SRPK2 Antibody - AF5530 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of MCF‑7 human breast cancer cell line, U937 human histiocytic lymphoma cell line, and A431 human epithelial carcinoma cell line. PVDF membrane was probed with 2 µg/mL of Human SRPK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5530) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for SRPK2 at approximately 115 to 120 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

SRPK2 Antibody - NBP1-87049 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SRPK2 Antibody [NBP1-87049] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

SRPK2 Antibody - NBP1-87048 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SRPK2 Antibody - NBP2-20484 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SRPK2 Antibody - H00006733-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

SRPK2 Antibody - NBP1-30114 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: SRPK2 Antibody [NBP1-30114] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- SRPK2 used at a dilution of 1:200 (1ug/ml). Detection: DAB

SRPK2 Polyclonal Antibody - bs-7923R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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