SRPK2

Gene Symbol	SRPK2
Entrez Gene	6733
Alt Symbol	SFRSK2
Species	Human
Gene Type	protein-coding
Description	SRSF protein kinase 2
Other Description	SFRS protein kinase 2|SR protein kinase 2|SR-protein-specific kinase 2|serine kinase SRPK2|serine/arginine-rich protein-specific kinase 2|serine/arginine-rich splicing factor kinase 2|serine/threonine-protein kinase SRPK2
Swissprots	Q6V1X2 O75220 P78362 O75221 Q8IYQ3 Q6NUL0 A8MVX2
Accessions	AAC29140 AAC29141 AAS00352 EAW83359 EAW83360 EAW83361 P78362 AK092977 AK093420 AW086157 AY354201 AAQ63886 BC035214 AAH35214 BC068547 AAH68547 BI918658 BM805927 BU632662 CR746049 DA592321 DQ891337 ABM82263 DQ894519 ABM85445 HY031357 U88666 AAC05299 XM_005250549 XP_005250606 XM_005250550 XP_005250607 XM_005250551 XP_005250608 XM_006716098 XP_006716161 XM_011516531 XP_011514833 XM_011516532 XP_011514834 XM_011516533 XP_011514835 XM_011516534 XP_011514836 XM_011516535 XP_011514837 XM_011516536 XP_011514838 XM_011516537 XP_011514839 XM_011516538 XP_011514840 XM_011516539 XP_011514841 XM_011516540 XP_011514842 XR_927524 XR_927525 XR_927526 NM_001278273 NP_001265202 NM_182691 NP_872633 NM_182692 NP_872634
Function	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reduc
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.
Tissue Specificity	Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. {ECO:0000269|PubMed:9472028}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SRPK2 full length protein - ab85293 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human SRPK2 full length protein - ab159580 from Abcam Category Protein Source Wheat germ Species Human

Human SRPK2 full length protein - ab159581 from Abcam Category Protein Source Wheat germ Species Human

Human SRPK2 full length protein - ab159582 from Abcam Category Protein Source Wheat germ Species Human

Human SRPK2 full length protein - ab159583 from Abcam Category Protein Source Wheat germ Species Human

Human SRPK2 protein fragment - ab159584 from Abcam Category Protein Source Wheat germ Species Human

SRPK2 Antibody Blocking Peptide - LS-E9046 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SRPK2 Protein - H00006733-P03 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SRPK2 Protein - H00006733-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SRPK2 Protein - H00006733-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SRPK2 Protein - H00006733-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SRPK2 Recombinant Protein - P4779 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

SRPK2 Peptide - P2563 from Novus Biologicals Category Peptide Species Human

SRPK2-Antibody-C-term-Blocking-Peptide - BP7553b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRPK2 - H00006733-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SRPK2 - H00006733-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SRPK2 - H00006733-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

SRPK2 - H00006733-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SRPK2 - H00006733-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SRPK2 - H00006733-P03 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

SRPK2 - H00006733-P03-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SRPK2 - H00006733-P03-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SRPK2 - H00006733-P04-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SRPK2 - H00006733-P04-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SRPK2 - H00006733-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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