| Gene Symbol |
PTRF
|
| Entrez Gene |
284119
|
| Alt Symbol |
CAVIN, CAVIN1, CGL4, FKSG13, cavin-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase I and transcript release factor
|
| Other Description |
RNA polymerase I and transcript release factor|TTF-I interacting peptide 12
|
| Swissprots |
Q9HAP4 B2RAW7 Q96H74 Q9BT85 Q6NZI2 Q6GMY1 O00535
|
| Accessions |
EAW60828 Q6NZI2 AF000421 AAC63404 AF312393 AAG27093 AK000715 AK074512 AK092406 BAG52547 AK298072 BAG60361 AK298563 BAG60757 AK314389 BAG37014 AL050224 BC004295 AAH04295 BC008849 AAH08849 BC066123 AAH66123 BC073759 AAH73759 XM_005257242 XP_005257299 NM_012232 NP_036364
|
| Function |
Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex. {ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}.
|
| Subcellular Location |
Membrane, caveola. Cell membrane {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Microsome {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Nucleus {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Note=Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane (By similarity). Co- localizes with CAV1 in lipid rafts in adipocytes. {ECO:0000250}.
|
![Western Blot: PTRF Overexpression Lysate (Adult Normal) [NBP2-04328] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PTRF.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9881_PTRF%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04328-img0001.jpg)