PTRF

Gene Symbol	PTRF
Entrez Gene	284119
Alt Symbol	CAVIN, CAVIN1, CGL4, FKSG13, cavin-1
Species	Human
Gene Type	protein-coding
Description	polymerase I and transcript release factor
Other Description	RNA polymerase I and transcript release factor|TTF-I interacting peptide 12
Swissprots	Q9HAP4 B2RAW7 Q96H74 Q9BT85 Q6NZI2 Q6GMY1 O00535
Accessions	EAW60828 Q6NZI2 AF000421 AAC63404 AF312393 AAG27093 AK000715 AK074512 AK092406 BAG52547 AK298072 BAG60361 AK298563 BAG60757 AK314389 BAG37014 AL050224 BC004295 AAH04295 BC008849 AAH08849 BC066123 AAH66123 BC073759 AAH73759 XM_005257242 XP_005257299 NM_012232 NP_036364
Function	Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex. {ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}.
Subcellular Location	Membrane, caveola. Cell membrane {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Microsome {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Nucleus {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Note=Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane (By similarity). Co- localizes with CAV1 in lipid rafts in adipocytes. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human PTRF full length protein - ab166163 from Abcam Category Protein Source Wheat germ Species Human

Human PTRF protein fragment - ab166164 from Abcam Category Protein Source Wheat germ Species Human

Mouse PTRF peptide - ab90995 from Abcam Category Peptide

PTRF peptide - ab88117 from Abcam Category Peptide

PTRF / CAVIN Antibody Blocking Peptide - LS-E8941 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTRF / CAVIN Antibody Blocking Peptide - LS-E8942 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTRF / CAVIN Antibody Blocking Peptide - LS-E13253 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTRF / CAVIN Antibody Blocking Peptide - LS-E31413 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human PTRF Protein - H00284119-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human PTRF Protein - H00284119-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PTRF-Antibody-C-term-Blocking-Peptide - BP7421b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTRF-Antibody-N-term-Blocking-Peptide - BP7421a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTRF Blocking Peptide - 33R-8384 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTRF - H00284119-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

PTRF - H00284119-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PTRF - H00284119-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PTRF Peptide - 7267P from ProSci Category Peptide Species Human

PTRF fusion protein - ag13495 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PTRF fusion protein - ag13486 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Polymerase I and transcript release factor,isoform 3(PTRF) - CSB-YP019070HU CSB-EP019070HU CSB-BP019070HU CSB-MP019070HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PTRF - TP309277 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Polymerase I and transcript release factor,isoform 3 (PTRF), Recombinant Protein - MBS1356537 from MyBioSource Category Protein Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,855.00, $1,855.00, $2,320.00, $2,320.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PTRF Recombinant Protein Antigen - NBP2-13828PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PTRF Peptide, Human - M34GP12733H from Creative Peptides Category Peptide Source Synthetic. Species Human

PTRF Recombinant Protein Antigen - NBP2-57490PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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