PTRF

Gene Symbol PTRF
Entrez Gene 284119
Alt Symbol CAVIN, CAVIN1, CGL4, FKSG13, cavin-1
Species Human
Gene Type protein-coding
Description polymerase I and transcript release factor
Other Description RNA polymerase I and transcript release factor|TTF-I interacting peptide 12
Swissprots Q9HAP4 B2RAW7 Q96H74 Q9BT85 Q6NZI2 Q6GMY1 O00535
Accessions EAW60828 Q6NZI2 AF000421 AAC63404 AF312393 AAG27093 AK000715 AK074512 AK092406 BAG52547 AK298072 BAG60361 AK298563 BAG60757 AK314389 BAG37014 AL050224 BC004295 AAH04295 BC008849 AAH08849 BC066123 AAH66123 BC073759 AAH73759 XM_005257242 XP_005257299 NM_012232 NP_036364
Function Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex. {ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}.
Subcellular Location Membrane, caveola. Cell membrane {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Microsome {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Nucleus {ECO:0000269|PubMed:15242332, ECO:0000269|PubMed:17026959}. Note=Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane (By similarity). Co- localizes with CAV1 in lipid rafts in adipocytes. {ECO:0000250}.

PTRF CRISPR/Cas9 KO Plasmid (h) - sc-404669 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTRF HDR Plasmid (h) - sc-404669-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTRF Double Nickase Plasmid (h) - sc-404669-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTRF Double Nickase Plasmid (h2) - sc-404669-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTRF CRISPR Activation Plasmid (h) - sc-404669-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTRF CRISPR Activation Plasmid (h2) - sc-404669-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTRF Lentiviral Activation Particles (h) - sc-404669-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTRF Lentiviral Activation Particles (h2) - sc-404669-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTRF siRNA (h) - sc-76293 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTRF shRNA Plasmid (h) - sc-76293-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTRF shRNA (h) Lentiviral Particles - sc-76293-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTRF RNAi - H00284119-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU152161 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17724 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17724 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PTRF siRNA (Human) - CRJ6975 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PTRF (NM_012232.5) - SHH386900 from Creative biogene

Category siRNA
Species Reactivities Human

Human PTRF siRNA - orb277476 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PTRF shRNA Plasmid (Human) - CHJ6975 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PTRF miRNA 3'UTR clone - MiUTR4H-TG07208 from Creative biogene

Species Reactivities Human
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