HSD17B8

Gene Symbol HSD17B8
Entrez Gene 7923
Alt Symbol D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9
Species Human
Gene Type protein-coding
Description hydroxysteroid (17-beta) dehydrogenase 8
Other Description 17-beta-HSD 8|17-beta-hydroxysteroid dehydrogenase 8|3-oxoacyl-[acyl-carrier-protein] reductase|estradiol 17-beta-dehydrogenase 8|estrogen 17-oxidoreductase|ke-6|protein Ke6|really interesting new gene 2 protein|short chain dehydrogenase/reductase family 30C member 1|short chain dehydrogenase/reductase family 30C, member 1|testosterone 17-beta-dehydrogenase 8
Swissprots A6NLX7 Q9UIQ1 Q92506 Q5STP7
Accessions CAC38444 EAX03682 Q92506 AM393508 CAL38385 AW025057 BC008185 AAH08185 BT007239 AAP35903 D82061 BAA11529 HY167181 NM_014234 NP_055049
Function NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. {ECO:0000269|PubMed:17978863, ECO:0000269|PubMed:19571038}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:19571038}.
Tissue Specificity Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed. {ECO:0000269|PubMed:17978863}.
Top Pathways Steroid hormone biosynthesis

17β-HSD8 (E-13) - sc-83768 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HSD17B8 antibody - ab197986 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HSD17B8 antibody (ab197986) at 1/650 dilution + Human testis tissue lysate at 40 µg

Anti-HSD17B8 antibody - ab67016 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-HSD17B8 antibody (ab67016) at 1/500 dilution + Human liver tissue lysate at 50 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugated secondary antibody at 1/2500 dilutiondeveloped using the ECL technique

Anti-HSD17B8 antibody - ab123005 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HSD17B8 antibody (ab123005) at 1 µg/ml + RPMI-8226 cell lysate at 10 µg

Anti-HSD17B8 antibody [EPR12084(B)] - ab169752 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12084(B)
Immunofluorescent analysis of JAR cells labelling HSD17B8 with ab169752 at 1/100 dilution.

Anti-HSD17B8 antibody [EPR12085(B)] - ab169542 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12085(B)
All lanes : Anti-HSD17B8 antibody [EPR12085(B)] (ab169542) at 1/10000 dilutionLane 1 : Human fetal liver lysateLane 2 : HepG2 lysateLane 3 : HeLa lysateLane 4 : Human fetal kidney lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit at 1/2000 dilution

Anti-HSD17B8 / RING2 Antibody (clone 4F1) - LS-C198512 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F1
HSD17B8 monoclonal antibody (M01), clone 4F1. Western Blot analysis of HSD17B8 expression in human pancreas.

Anti-HSD17B8 / RING2 Antibody (aa57-261, clone 2E12) - LS-C336980 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E12
IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-HSD17B8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-HSD17B8 / RING2 Antibody (clone 6H2) - LS-C175393 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6H2
IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-HSD17B8 mouse monoclonal antibody.

Anti-HSD17B8 / RING2 Antibody - LS-C311236 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HSD17B8 / RING2 Antibody - LS-C308326 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HSD17B8 / RING2 Antibody - LS-C311237 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HSD17B8 / RING2 Antibody (aa51-100) - LS-C146002 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HSD17B8 antibody LS-C146002 Western blot of 8226 Cell lysate. Antibody concentration 1 ug/ml.

HSD17B8 Antibody - NBP1-84309 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HSD17B8 Antibody - H00007923-B02P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: HSD17B8 Antibody [H00007923-B02P] - Analysis of HSD17B8 expression in human liver.

HSD17B8 Antibody - H00007923-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: HSD17B8 Antibody [H00007923-B01P] - Analysis of HSD17B8 expression in human liver.

HSD17B8 Antibody - H00007923-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: HSD17B8 Antibody [H00007923-B01] - D17B8 MaxPab polyclonal antibody (B01), Lot # 08101 WULz. Western Blot analysis of HSD17B8 expression in human liver.

HSD17B8 Antibody - H00007923-B02 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: HSD17B8 Antibody [H00007923-B02] - D17B8 MaxPab polyclonal antibody (B02), Lot # 08046 WULz. Western Blot analysis of HSD17B8 expression in human liver.

HSD17B8 Antibody (4F1) - H00007923-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F1
Western Blot: HSD17B8 Antibody (4F1) [H00007923-M01] - HSD17B8 monoclonal antibody (M01), clone 4F1. Analysis of HSD17B8 expression in human pancreas.

HSD17B8 Antibody - H00007923-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HSD17B8 Antibody [H00007923-D01P] - Analysis of HSD17B8 expression in transfected 293T cell line by HSD17B8 polyclonal antibody.Lane 1: HSD17B8 transfected lysate(27.00 KDa).Lane 2: Non-transfected lysate.

HSD17B8 Antibody - H00007923-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HSD17B8 Polyclonal Antibody - bs-11407R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HSD17B8 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11407R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HSD17B8 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11407R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HSD17B8 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11407R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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