| Gene Symbol |
HSD17B8
|
| Entrez Gene |
7923
|
| Alt Symbol |
D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxysteroid (17-beta) dehydrogenase 8
|
| Other Description |
17-beta-HSD 8|17-beta-hydroxysteroid dehydrogenase 8|3-oxoacyl-[acyl-carrier-protein] reductase|estradiol 17-beta-dehydrogenase 8|estrogen 17-oxidoreductase|ke-6|protein Ke6|really interesting new gene 2 protein|short chain dehydrogenase/reductase family 30C member 1|short chain dehydrogenase/reductase family 30C, member 1|testosterone 17-beta-dehydrogenase 8
|
| Swissprots |
A6NLX7 Q9UIQ1 Q92506 Q5STP7
|
| Accessions |
CAC38444 EAX03682 Q92506 AM393508 CAL38385 AW025057 BC008185 AAH08185 BT007239 AAP35903 D82061 BAA11529 HY167181 NM_014234 NP_055049
|
| Function |
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. {ECO:0000269|PubMed:17978863, ECO:0000269|PubMed:19571038}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:19571038}.
|
| Tissue Specificity |
Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed. {ECO:0000269|PubMed:17978863}.
|
| Top Pathways |
Steroid hormone biosynthesis
|
