| Gene Symbol |
SUSD2
|
| Entrez Gene |
56241
|
| Alt Symbol |
BK65A6.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sushi domain containing 2
|
| Other Description |
Sushi domain (SCR repeat) containing|sushi domain-containing protein 2
|
| Swissprots |
Q9UGT4 Q9H5Y6
|
| Accessions |
CAB62953 EAW59641 EAW59642 Q9UGT4 AK026431 BAB15481 AK126105 BC033107 AAH33107 BI822588 NM_019601 NP_062547
|
| Function |
May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}; Single-pass type I membrane protein {ECO:0000305}. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells. {ECO:0000269|PubMed:23131994}.
|
| Tissue Specificity |
Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tisues (PubMed:25351403). {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}.
|