Gene Symbol | SUSD2 |
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Entrez Gene | 56241 |
Alt Symbol | BK65A6.2 |
Species | Human |
Gene Type | protein-coding |
Description | sushi domain containing 2 |
Other Description | Sushi domain (SCR repeat) containing|sushi domain-containing protein 2 |
Swissprots | Q9UGT4 Q9H5Y6 |
Accessions | CAB62953 EAW59641 EAW59642 Q9UGT4 AK026431 BAB15481 AK126105 BC033107 AAH33107 BI822588 NM_019601 NP_062547 |
Function | May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}; Single-pass type I membrane protein {ECO:0000305}. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells. {ECO:0000269|PubMed:23131994}. |
Tissue Specificity | Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tisues (PubMed:25351403). {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}. |
SUSD2 CRISPR/Cas9 KO Plasmid (h) - sc-412691 from Santa Cruz Biotechnology
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SUSD2 HDR Plasmid (h) - sc-412691-HDR from Santa Cruz Biotechnology
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SUSD2 Double Nickase Plasmid (h) - sc-412691-NIC from Santa Cruz Biotechnology
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SUSD2 Double Nickase Plasmid (h2) - sc-412691-NIC-2 from Santa Cruz Biotechnology
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SUSD2 CRISPR Activation Plasmid (h) - sc-412691-ACT from Santa Cruz Biotechnology
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SUSD2 CRISPR Activation Plasmid (h2) - sc-412691-ACT-2 from Santa Cruz Biotechnology
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SUSD2 Lentiviral Activation Particles (h) - sc-412691-LAC from Santa Cruz Biotechnology
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SUSD2 Lentiviral Activation Particles (h2) - sc-412691-LAC-2 from Santa Cruz Biotechnology
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SUSD2 siRNA (h) - sc-76617 from Santa Cruz Biotechnology
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SUSD2 shRNA Plasmid (h) - sc-76617-SH from Santa Cruz Biotechnology
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SUSD2 shRNA (h) Lentiviral Particles - sc-76617-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU148911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20853 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20853 from Sigma-Aldrich
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SUSD2 siRNA (Human) - CRJ1109 from Cohesion Biosciences
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SUSD2 - MBS8235703 from MyBioSource
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shRNA set against Human SUSD2 (NM_019601.3) - SHH421136 from Creative biogene
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SUSD2 shRNA Plasmid (Human) - CHJ1109 from Cohesion Biosciences
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SUSD2 miRNA 3'UTR clone - MiUTR1H-10081 from Creative biogene
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