USP20

Gene Symbol USP20
Entrez Gene 10868
Alt Symbol LSFR3A, VDU2, hVDU2
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 20
Other Description deubiquitinating enzyme 20|pVHL-interacting deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 20|ubiquitin thioesterase 20|ubiquitin thiolesterase 20|ubiquitin-specific-processing protease 20
Swissprots Q9UQN8 Q96LG5 Q541F1 Q9Y2K6 Q8IXQ1 Q9UQP0
Accessions CAB44350 CAB44351 CAB44352 EAW87911 EAW87912 EAW87913 EAW87914 EAW87915 Q9Y2K6 AB023220 BAA76847 AY074877 AAL79676 BC033669 BC039593 AAH39593 BF727180 BM678735 BP246486 BQ882312 BX462233 DA791069 XM_005251665 XP_005251722 XM_005251666 XP_005251723 XM_011518161 XP_011516463 XM_011518162 XP_011516464 NM_001008563 NP_001008563 NM_001110303 NP_001103773 NM_006676 NP_006667
Function Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubM
Subcellular Location Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.

USP20 (D-19) - sc-69168 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-USP20 antibody - ab150741 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal medulla tissue labelled with ab150741 at 10 µg/ml.

Anti-USP20 antibody - ab72225 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-USP20 antibody (ab72225) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-USP20 antibody - ab119918 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-USP20 antibody (ab119918) at 1/1000 dilutionLane 1 : 293T cell lysate Lane 2 : Human fetal brain lysateLane 3 : Human fetal heart lysate

Anti-USP20 antibody - ab5272 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab5272 at 3ug/ml staining USP20 in human lymph node tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in microwave in Tris/EDTA buffer (pH 9.0). The HRP-staining procedure was used for detection.

Anti-USP20 antibody - ab56789 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56789 USP20 antibody at 1ug/ml.

Anti-USP20 antibody - ab62055 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab62055, at 10µg/ml, staining Human USP20 in adrenal medulla, using Immunohistochemistry, Formalin/PFA-fixed Paraffin embedded tissue.

Anti-USP20 / VDU2 Antibody (aa863-913) - LS-C76706 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (aa902-914) - LS-C55654 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (aa309-339, AP) - LS-C224613 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (aa309-339, APC) - LS-C224614 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (aa309-339, Biotin) - LS-C224615 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (aa309-339, Azide-free, HRP) - LS-C224617 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (aa309-339, FITC) - LS-C224616 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (N-Terminus, AP) - LS-C226643 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (N-Terminus, APC) - LS-C226644 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (aa309-339, PE) - LS-C224618 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (N-Terminus, Biotin) - LS-C226645 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (N-Terminus, FITC) - LS-C226646 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (N-Terminus, PE) - LS-C226648 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (N-Terminus, Azide-free, HRP) - LS-C226647 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (C-Terminus, AP) - LS-C226649 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (C-Terminus, Biotin) - LS-C226651 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (C-Terminus, APC) - LS-C226650 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP20 / VDU2 Antibody (aa361-410) - LS-C116883 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
USP20 antibody LS-C116883 Western blot of Fetal Heart lysate.
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