USP20

Gene Symbol USP20
Entrez Gene 10868
Alt Symbol LSFR3A, VDU2, hVDU2
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 20
Other Description deubiquitinating enzyme 20|pVHL-interacting deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 20|ubiquitin thioesterase 20|ubiquitin thiolesterase 20|ubiquitin-specific-processing protease 20
Swissprots Q9UQN8 Q96LG5 Q541F1 Q9Y2K6 Q8IXQ1 Q9UQP0
Accessions CAB44350 CAB44351 CAB44352 EAW87911 EAW87912 EAW87913 EAW87914 EAW87915 Q9Y2K6 AB023220 BAA76847 AY074877 AAL79676 BC033669 BC039593 AAH39593 BF727180 BM678735 BP246486 BQ882312 BX462233 DA791069 XM_005251665 XP_005251722 XM_005251666 XP_005251723 XM_011518161 XP_011516463 XM_011518162 XP_011516464 NM_001008563 NP_001008563 NM_001110303 NP_001103773 NM_006676 NP_006667
Function Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubM
Subcellular Location Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.

DUSP20 CRISPR/Cas9 KO Plasmid (h) - sc-406849 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DUSP20 HDR Plasmid (h) - sc-406849-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DUSP20 Double Nickase Plasmid (h) - sc-406849-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DUSP20 Double Nickase Plasmid (h2) - sc-406849-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DUSP20 CRISPR Activation Plasmid (h) - sc-406849-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DUSP20 CRISPR Activation Plasmid (h2) - sc-406849-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DUSP20 Lentiviral Activation Particles (h) - sc-406849-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DUSP20 Lentiviral Activation Particles (h2) - sc-406849-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP20 siRNA (h) - sc-76823 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP20 shRNA Plasmid (h) - sc-76823-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP20 shRNA (h) Lentiviral Particles - sc-76823-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP20 RNAi - H00010868-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

USP20 RNAi - H00010868-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

USP20 RNAi - H00010868-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU071951 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22569 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22569 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12704 from Sigma-Aldrich

Category miRNA

USP20 siRNA (Human) - CRH7401 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP20 - MBS8216167 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human USP20 (NM_006676.6) - SHH441352 from Creative biogene

Category siRNA
Species Reactivities Human

USP20 shRNA Plasmid (Human) - CHH7401 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

USP20 miRNA 3'UTR clone - MiUTR3H-15101 from Creative biogene

Species Reactivities Human

USP20 miRNA 3'UTR clone - MiUTR3H-15102 from Creative biogene

Species Reactivities Human

USP20 miRNA 3'UTR clone - MiUTR3H-15103 from Creative biogene

Species Reactivities Human
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