| Gene Symbol |
USP20
|
| Entrez Gene |
10868
|
| Alt Symbol |
LSFR3A, VDU2, hVDU2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 20
|
| Other Description |
deubiquitinating enzyme 20|pVHL-interacting deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 20|ubiquitin thioesterase 20|ubiquitin thiolesterase 20|ubiquitin-specific-processing protease 20
|
| Swissprots |
Q9UQN8 Q96LG5 Q541F1 Q9Y2K6 Q8IXQ1 Q9UQP0
|
| Accessions |
CAB44350 CAB44351 CAB44352 EAW87911 EAW87912 EAW87913 EAW87914 EAW87915 Q9Y2K6 AB023220 BAA76847 AY074877 AAL79676 BC033669 BC039593 AAH39593 BF727180 BM678735 BP246486 BQ882312 BX462233 DA791069 XM_005251665 XP_005251722 XM_005251666 XP_005251723 XM_011518161 XP_011516463 XM_011518162 XP_011516464 NM_001008563 NP_001008563 NM_001110303 NP_001103773 NM_006676 NP_006667
|
| Function |
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubM
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
|