USP20

Gene Symbol	USP20
Entrez Gene	10868
Alt Symbol	LSFR3A, VDU2, hVDU2
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 20
Other Description	deubiquitinating enzyme 20|pVHL-interacting deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 20|ubiquitin thioesterase 20|ubiquitin thiolesterase 20|ubiquitin-specific-processing protease 20
Swissprots	Q9UQN8 Q96LG5 Q541F1 Q9Y2K6 Q8IXQ1 Q9UQP0
Accessions	CAB44350 CAB44351 CAB44352 EAW87911 EAW87912 EAW87913 EAW87914 EAW87915 Q9Y2K6 AB023220 BAA76847 AY074877 AAL79676 BC033669 BC039593 AAH39593 BF727180 BM678735 BP246486 BQ882312 BX462233 DA791069 XM_005251665 XP_005251722 XM_005251666 XP_005251723 XM_011518161 XP_011516463 XM_011518162 XP_011516464 NM_001008563 NP_001008563 NM_001110303 NP_001103773 NM_006676 NP_006667
Function	Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubM
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP20 293T Cell Transient Overexpression Lysate(Denatured) - H00010868-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

USP20 overexpression lysate - LY402002 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

USP20 overexpression lysate - LY423335 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

USP20 293 Cell Lysate - 401780 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

USP20 293 Cell Lysate - 409913 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

USP20 Overexpression Lysate (Denatured) - H00010868-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

USP20 Overexpression Lysate (Native) - NBL1-17651 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

USP20 Overexpression Lysate (Native) - NBL1-17652 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

USP20 Over-expression Lysate Product - GWB-B8C053 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

USP20 Over-expression Lysate Product - GWB-9BDB58 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human USP20 Knockdown Stable Cell Line - CSC-DC017164 from Creative biogene Category Cell Line Species Human

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