| Gene Symbol |
SPON2
|
| Entrez Gene |
10417
|
| Alt Symbol |
DIL-1, DIL1, M-SPONDIN, MINDIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spondin 2, extracellular matrix protein
|
| Other Description |
differentially expressed in cancerous and non-cancerous lung cells 1|spondin-2
|
| Swissprots |
Q9ULW1 Q9BUD6 Q4W5N4 D3DVN9
|
| Accessions |
AAY40988 CAF85941 EAW82604 EAW82605 EAW82606 Q9BUD6 AA864573 AB027466 BAA85892 AK024499 BAB15789 AK026054 AK074618 BAC11092 AK074770 BAC11196 AK130164 AY358948 AAQ89307 BC002707 AAH02707 BC036341 AAH36341 BC086866 BY797606 CB104725 DA087369 DA092888 DA201089 DA375259 DB249869 DB254983 NM_001128325 NP_001121797 NM_001199021 NP_001185950 NM_012445 NP_036577
|
| Function |
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Tissue Specificity |
Expressed in normal lung tissue but not in lung carcinoma cell lines. {ECO:0000269|PubMed:10512675}.
|