Gene Symbol | SPON2 |
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Entrez Gene | 10417 |
Alt Symbol | DIL-1, DIL1, M-SPONDIN, MINDIN |
Species | Human |
Gene Type | protein-coding |
Description | spondin 2, extracellular matrix protein |
Other Description | differentially expressed in cancerous and non-cancerous lung cells 1|spondin-2 |
Swissprots | Q9ULW1 Q9BUD6 Q4W5N4 D3DVN9 |
Accessions | AAY40988 CAF85941 EAW82604 EAW82605 EAW82606 Q9BUD6 AA864573 AB027466 BAA85892 AK024499 BAB15789 AK026054 AK074618 BAC11092 AK074770 BAC11196 AK130164 AY358948 AAQ89307 BC002707 AAH02707 BC036341 AAH36341 BC086866 BY797606 CB104725 DA087369 DA092888 DA201089 DA375259 DB249869 DB254983 NM_001128325 NP_001121797 NM_001199021 NP_001185950 NM_012445 NP_036577 |
Function | Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
Tissue Specificity | Expressed in normal lung tissue but not in lung carcinoma cell lines. {ECO:0000269|PubMed:10512675}. |
Mindin CRISPR/Cas9 KO Plasmid (h) - sc-417294 from Santa Cruz Biotechnology
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Mindin HDR Plasmid (h) - sc-417294-HDR from Santa Cruz Biotechnology
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Mindin Double Nickase Plasmid (h) - sc-417294-NIC from Santa Cruz Biotechnology
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Mindin Double Nickase Plasmid (h2) - sc-417294-NIC-2 from Santa Cruz Biotechnology
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Mindin CRISPR Activation Plasmid (h) - sc-417294-ACT from Santa Cruz Biotechnology
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Mindin CRISPR Activation Plasmid (h2) - sc-417294-ACT-2 from Santa Cruz Biotechnology
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Mindin Lentiviral Activation Particles (h) - sc-417294-LAC from Santa Cruz Biotechnology
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Mindin Lentiviral Activation Particles (h2) - sc-417294-LAC-2 from Santa Cruz Biotechnology
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Mindin siRNA (h) - sc-61046 from Santa Cruz Biotechnology
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Mindin shRNA Plasmid (h) - sc-61046-SH from Santa Cruz Biotechnology
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Mindin shRNA (h) Lentiviral Particles - sc-61046-V from Santa Cruz Biotechnology
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Mindin/Spondin-2 RNAi - H00010417-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN20506 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20506 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04621 from Sigma-Aldrich
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SPON2 siRNA (Human) - CRH7062 from Cohesion Biosciences
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SPON2 - MBS8241202 from MyBioSource
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shRNA set against Human Spon2 (NM_012445.3) - SHH417076 from Creative biogene
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Human SPON2 siRNA - orb267564 from Biorbyt
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SPON2 shRNA Plasmid (Human) - CHH7062 from Cohesion Biosciences
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SPON2 miRNA 3'UTR clone - MiUTR3H-08042 from Creative biogene
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SPON2 miRNA 3'UTR clone - MiUTR3H-08043 from Creative biogene
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