| Gene Symbol |
PBXIP1
|
| Entrez Gene |
57326
|
| Alt Symbol |
HPIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pre-B-cell leukemia homeobox interacting protein 1
|
| Other Description |
hematopoietic PBX-interacting protein|pre-B-cell leukemia transcription factor interacting protein 1|pre-B-cell leukemia transcription factor-interacting protein 1
|
| Swissprots |
Q9HD85 Q5T176 Q5T174 Q96AQ6 Q9HA02 Q9H8X6
|
| Accessions |
EAW53174 EAW53175 EAW53176 Q96AQ6 AF221521 AAG02026 AK022497 BAB14059 AK023219 BAB14471 AK300544 BAG62252 AK300987 BAG62606 AK303413 BAG64466 AK303863 BAG64802 AK310388 AK310712 AK315551 BC016852 AAH16852 EU446600 ABZ92129 U00952 NM_020524 NP_065385
|
| Function |
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.
|
| Tissue Specificity |
Expressed in early hematopoietic precursors. {ECO:0000269|PubMed:10825160}.
|
![Western Blot: PBXIP1 Overexpression Lysate (Adult Normal) [NBP2-06635] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PBXIP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7776_PBXIP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06635-img0001.jpg)