Gene Symbol | PBXIP1 |
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Entrez Gene | 57326 |
Alt Symbol | HPIP |
Species | Human |
Gene Type | protein-coding |
Description | pre-B-cell leukemia homeobox interacting protein 1 |
Other Description | hematopoietic PBX-interacting protein|pre-B-cell leukemia transcription factor interacting protein 1|pre-B-cell leukemia transcription factor-interacting protein 1 |
Swissprots | Q9HD85 Q5T176 Q5T174 Q96AQ6 Q9HA02 Q9H8X6 |
Accessions | EAW53174 EAW53175 EAW53176 Q96AQ6 AF221521 AAG02026 AK022497 BAB14059 AK023219 BAB14471 AK300544 BAG62252 AK300987 BAG62606 AK303413 BAG64466 AK303863 BAG64802 AK310388 AK310712 AK315551 BC016852 AAH16852 EU446600 ABZ92129 U00952 NM_020524 NP_065385 |
Function | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
Subcellular Location | Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus. |
Tissue Specificity | Expressed in early hematopoietic precursors. {ECO:0000269|PubMed:10825160}. |
PBXIP1 CRISPR/Cas9 KO Plasmid (h) - sc-412788 from Santa Cruz Biotechnology
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PBXIP1 HDR Plasmid (h) - sc-412788-HDR from Santa Cruz Biotechnology
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PBXIP1 Double Nickase Plasmid (h) - sc-412788-NIC from Santa Cruz Biotechnology
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PBXIP1 Double Nickase Plasmid (h2) - sc-412788-NIC-2 from Santa Cruz Biotechnology
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PBXIP1 CRISPR Activation Plasmid (h) - sc-412788-ACT from Santa Cruz Biotechnology
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PBXIP1 CRISPR Activation Plasmid (h2) - sc-412788-ACT-2 from Santa Cruz Biotechnology
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PBXIP1 Lentiviral Activation Particles (h) - sc-412788-LAC from Santa Cruz Biotechnology
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PBXIP1 Lentiviral Activation Particles (h2) - sc-412788-LAC-2 from Santa Cruz Biotechnology
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PBXIP1 siRNA (h) - sc-88118 from Santa Cruz Biotechnology
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PBXIP1 shRNA Plasmid (h) - sc-88118-SH from Santa Cruz Biotechnology
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PBXIP1 shRNA (h) Lentiviral Particles - sc-88118-V from Santa Cruz Biotechnology
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PBXIP1 RNAi - H00057326-R01 from Novus Biologicals
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MISSION® esiRNA - EHU098781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16387 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16387 from Sigma-Aldrich
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PBXIP1 siRNA (Human) - CRJ1414 from Cohesion Biosciences
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shRNA set against Human PBXIP1 (NM_020524.2) - SHH371332 from Creative biogene
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PBXIP1 shRNA Plasmid (Human) - CHJ1414 from Cohesion Biosciences
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PBXIP1 miRNA 3'UTR clone - MiUTR1H-07550 from Creative biogene
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