| Gene Symbol |
NMNAT2
|
| Entrez Gene |
23057
|
| Alt Symbol |
C1orf15, PNAT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nicotinamide nucleotide adenylyltransferase 2
|
| Other Description |
NMN adenylyltransferase 2|NMN/NaMN adenylyltransferase 2|NaMN adenylyltransferase 2|nicotinamide mononucleotide adenylyltransferase 2|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2|nicotinate-nucleotide adenylyltransferase 2|pyridine nucleotide adenylyltransferase 2
|
| Swissprots |
Q96QW1 O75067 Q9BZQ4 Q5T1Q3 Q8WU99
|
| Accessions |
CAM12698 CDH92522 EAW91148 EAW91149 EAW91150 EAW91151 Q9BZQ4 AB007948 BAA32324 AF086038 AF288395 AAG60615 AK291390 BAF84079 AK309461 BC016726 BC020998 AAH20998 BC037251 BI493003 HQ447356 ADQ31842 NM_015039 NP_055854 NM_170706 NP_733820
|
| Function |
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16118205}. Golgi apparatus {ECO:0000269|PubMed:16118205}.
|
| Tissue Specificity |
Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. {ECO:0000269|PubMed:12359228, ECO:0000269|PubMed:14516279, ECO:0000269|PubMed:16118205}.
|
| Top Pathways |
Nicotinate and nicotinamide metabolism
|
![Western Blot: NMNAT2 Overexpression Lysate (Adult Normal) [NBL1-13692] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NMNAT2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26222_NMNAT2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13692-img0002.jpg)