NMNAT2

Gene Symbol	NMNAT2
Entrez Gene	23057
Alt Symbol	C1orf15, PNAT2
Species	Human
Gene Type	protein-coding
Description	nicotinamide nucleotide adenylyltransferase 2
Other Description	NMN adenylyltransferase 2|NMN/NaMN adenylyltransferase 2|NaMN adenylyltransferase 2|nicotinamide mononucleotide adenylyltransferase 2|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2|nicotinate-nucleotide adenylyltransferase 2|pyridine nucleotide adenylyltransferase 2
Swissprots	Q96QW1 O75067 Q9BZQ4 Q5T1Q3 Q8WU99
Accessions	CAM12698 CDH92522 EAW91148 EAW91149 EAW91150 EAW91151 Q9BZQ4 AB007948 BAA32324 AF086038 AF288395 AAG60615 AK291390 BAF84079 AK309461 BC016726 BC020998 AAH20998 BC037251 BI493003 HQ447356 ADQ31842 NM_015039 NP_055854 NM_170706 NP_733820
Function	Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16118205}. Golgi apparatus {ECO:0000269|PubMed:16118205}.
Tissue Specificity	Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. {ECO:0000269|PubMed:12359228, ECO:0000269|PubMed:14516279, ECO:0000269|PubMed:16118205}.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NMNAT-2 (H-100) - sc-134935 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

NMNAT-2 (C-20) - sc-55861 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

NMNAT-2 (V-20) - sc-55864 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-NMNAT2 antibody - ab56980 from Abcam Prices $385.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-NMNAT2 antibody - ab130584 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody (aa13-40) - LS-C158404 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody - LS-C345046 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Guinea Pig Clonality Polyclonal

Anti-NMNAT2 Antibody (clone 4E6) - LS-C139230 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4E6

Anti-NMNAT2 Antibody (aa13-40, AP) - LS-C223478 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody (aa13-40, APC) - LS-C223479 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody (aa13-40, Biotin) - LS-C223480 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody (aa13-40, FITC) - LS-C223481 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody (aa13-40, Azide-free, HRP) - LS-C223482 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody (aa13-40, PE) - LS-C223483 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody (aa12-40) - LS-C323379 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NMNAT2 Antibody (clone Nady-1) - LS-C344914 from LifeSpan Bioscience Prices $275.00, $325.00 Sizes 50 µg, 100 µg Host Mouse Clonality Monoclonal Clone Nady-1

NMNAT-2 Antibody (2G8) - H00023057-M04 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G8

NMNAT-2 Antibody (2E4) - H00023057-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2E4

NMNAT-2 Antibody (4E6) - H00023057-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4E6

NMNAT-2 Antibody - H00023057-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Monoclonal Anti-NMNAT2 antibody produced in mouse - SAB1409014 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G8

Monoclonal Anti-NMNAT2, (C-terminal) antibody produced in mouse - SAB1404951 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4E6

Monoclonal Anti-NMNAT2 antibody produced in mouse - WH0023057M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2E4

NMNAT2-Antibody-N-term - AP17277a from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

NMNAT2-Antibody-monoclonal-M01 - AT3072a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2E5

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