NMNAT2

Gene Symbol	NMNAT2
Entrez Gene	23057
Alt Symbol	C1orf15, PNAT2
Species	Human
Gene Type	protein-coding
Description	nicotinamide nucleotide adenylyltransferase 2
Other Description	NMN adenylyltransferase 2|NMN/NaMN adenylyltransferase 2|NaMN adenylyltransferase 2|nicotinamide mononucleotide adenylyltransferase 2|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2|nicotinate-nucleotide adenylyltransferase 2|pyridine nucleotide adenylyltransferase 2
Swissprots	Q96QW1 O75067 Q9BZQ4 Q5T1Q3 Q8WU99
Accessions	CAM12698 CDH92522 EAW91148 EAW91149 EAW91150 EAW91151 Q9BZQ4 AB007948 BAA32324 AF086038 AF288395 AAG60615 AK291390 BAF84079 AK309461 BC016726 BC020998 AAH20998 BC037251 BI493003 HQ447356 ADQ31842 NM_015039 NP_055854 NM_170706 NP_733820
Function	Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16118205}. Golgi apparatus {ECO:0000269|PubMed:16118205}.
Tissue Specificity	Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. {ECO:0000269|PubMed:12359228, ECO:0000269|PubMed:14516279, ECO:0000269|PubMed:16118205}.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NMNAT2 full length protein - ab171475 from Abcam Category Protein Source E. coli Species Human

NMNAT2 Antibody Blocking Peptide - LS-E4896 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMNAT-2 Recombinant Protein - H00023057-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NMNAT-2 Partial Recombinant Protein - H00023057-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NMNAT-2 Recombinant Protein - H00023057-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NMNAT-2 Protein - NBP2-23285 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Species Human

NMNAT2-Antibody-N-term-Blocking-Peptide - BP17277a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human NMNAT-2, CF - 6279-NT-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Met1-Glu307, with a C-terminal 6-His tag

Human NMNAT2 protein (His Tag) - orb139401 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

NMNAT2 protein (His tag) - 80R-3516 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

NMNAT2 (1-307, His-tag) - AR51205PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

NMNAT2 (1-307, His-tag) - AR51205PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

NMNAT2 - H00023057-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NMNAT2 - H00023057-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NMNAT2 - H00023057-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

NMNAT2 - H00023057-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NMNAT2 - H00023057-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NMNAT2 - H00023057-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NMNAT2 - H00023057-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NMNAT2, 1-307 aa, Human, His tag, E.coli - 01-P2383 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

Recombinant Human NMNAT2, His-tagged - NMNAT2-28747TH from Creative Biomart Category Protein Source E. coli

Recombinant Human NMNAT2, His tagged - NMNAT2-251H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Recombinant Human nicotinamide nucleotide adenylyltransferase 2, His-tagged - NMNAT2-300H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human NMNAT2, His-tagged - NMNAT2-638H from Creative Biomart Category Protein Source E.coli.

Human NMNAT2 / NMNAT-2 Protein (His Tag) - 11399-H08B-10 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 10 µg, 20 µg Source Baculovirus-Insect Cells Species Human

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