NMNAT2
| Gene Symbol | NMNAT2 |
|---|---|
| Entrez Gene | 23057 |
| Alt Symbol | C1orf15, PNAT2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nicotinamide nucleotide adenylyltransferase 2 |
| Other Description | NMN adenylyltransferase 2|NMN/NaMN adenylyltransferase 2|NaMN adenylyltransferase 2|nicotinamide mononucleotide adenylyltransferase 2|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2|nicotinate-nucleotide adenylyltransferase 2|pyridine nucleotide adenylyltransferase 2 |
| Swissprots | Q96QW1 O75067 Q9BZQ4 Q5T1Q3 Q8WU99 |
| Accessions | CAM12698 CDH92522 EAW91148 EAW91149 EAW91150 EAW91151 Q9BZQ4 AB007948 BAA32324 AF086038 AF288395 AAG60615 AK291390 BAF84079 AK309461 BC016726 BC020998 AAH20998 BC037251 BI493003 HQ447356 ADQ31842 NM_015039 NP_055854 NM_170706 NP_733820 |
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16118205}. Golgi apparatus {ECO:0000269|PubMed:16118205}. |
| Tissue Specificity | Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. {ECO:0000269|PubMed:12359228, ECO:0000269|PubMed:14516279, ECO:0000269|PubMed:16118205}. |
| Top Pathways | Nicotinate and nicotinamide metabolism |
NMNAT-2 CRISPR/Cas9 KO Plasmid (h) - sc-403330 from Santa Cruz Biotechnology
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NMNAT-2 HDR Plasmid (h) - sc-403330-HDR from Santa Cruz Biotechnology
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NMNAT-2 Double Nickase Plasmid (h) - sc-403330-NIC from Santa Cruz Biotechnology
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NMNAT-2 Double Nickase Plasmid (h2) - sc-403330-NIC-2 from Santa Cruz Biotechnology
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NMNAT-2 CRISPR Activation Plasmid (h) - sc-403330-ACT from Santa Cruz Biotechnology
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NMNAT-2 CRISPR Activation Plasmid (h2) - sc-403330-ACT-2 from Santa Cruz Biotechnology
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NMNAT-2 Lentiviral Activation Particles (h) - sc-403330-LAC from Santa Cruz Biotechnology
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NMNAT-2 Lentiviral Activation Particles (h2) - sc-403330-LAC-2 from Santa Cruz Biotechnology
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NMNAT-2 siRNA (h) - sc-62693 from Santa Cruz Biotechnology
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NMNAT-2 shRNA Plasmid (h) - sc-62693-SH from Santa Cruz Biotechnology
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NMNAT-2 shRNA (h) Lentiviral Particles - sc-62693-V from Santa Cruz Biotechnology
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NMNAT-2 RNAi - H00023057-R02 from Novus Biologicals
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NMNAT-2 RNAi - H00023057-R01 from Novus Biologicals
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MISSION® esiRNA - EHU058901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15376 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15376 from Sigma-Aldrich
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NMNAT2 siRNA (Human) - CRH7965 from Cohesion Biosciences
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shRNA set against Human NMNAT2 (NM_015039.3) - SHH353236 from Creative biogene
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Human NMNAT2 siRNA - orb268467 from Biorbyt
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NMNAT2 shRNA Plasmid (Human) - CHH7965 from Cohesion Biosciences
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