Gene Symbol | TULP1 |
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Entrez Gene | 7287 |
Alt Symbol | LCA15, RP14, TUBL1 |
Species | Human |
Gene Type | protein-coding |
Description | tubby like protein 1 |
Other Description | tubby-related protein 1 |
Swissprots | O43536 Q5TGM5 Q8N571 O00294 |
Accessions | AAB97966 EAX03839 EAX03840 O00294 AB593123 BAJ84063 AB593124 BAJ84064 BC032714 AAH32714 BC065261 AAH65261 CN355966 DQ426893 ABD90544 EU446712 ABZ92241 U82468 AAB53700 NM_001289395 NP_001276324 NM_003322 NP_003313 |
Function | Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:16303976, ECO:0000269|PubMed:19837063}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16303976}. Cell membrane {ECO:0000269|PubMed:16303976}; Peripheral membrane protein {ECO:0000269|PubMed:16303976}; Cytoplasmic side {ECO:0000269|PubMed:16303976}. Secreted {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By similarity). {ECO:0000250}. |
Tissue Specificity | Retina-specific. |
TULP1 (N-19) - sc-7684 from Santa Cruz Biotechnology
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Anti-TULP1 antibody - ab97281 from Abcam
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Anti-TULP1 antibody - ab94557 from Abcam
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Anti-TULP1 antibody - ab130555 from Abcam
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Anti-TULP1 antibody - ab17364 from Abcam
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Anti-TULP1 Antibody (aa183-211, AP) - LS-C218212 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa183-211, APC) - LS-C218213 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa183-211, Biotin) - LS-C218214 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa183-211, FITC) - LS-C218215 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa183-211, PE) - LS-C218217 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa183-211, Azide-free, HRP) - LS-C218216 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa183-211) - LS-C326103 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa251-300) - LS-C109802 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa183-211) - LS-C160343 from LifeSpan Bioscience
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Anti-TULP1 Antibody (aa281-542) - LS-C185581 from LifeSpan Bioscience
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TULP1 Antibody - NBP1-31401 from Novus Biologicals
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ANTI-TULP1 (CENTER) antibody produced in rabbit - SAB1304878 from Sigma-Aldrich
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Anti-TULP1 antibody produced in rabbit - SAB2700274 from Sigma-Aldrich
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Anti-TULP1 antibody produced in rabbit - SAB2104188 from Sigma-Aldrich
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TULP1 antibody - middle region (ARP33469_P050) - ARP33469_P050 from Aviva Systems Biology
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TULP1-Antibody-Center - AP17083c from Abgent, a WuXi AppTec company
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TULP1 Antibody - middle region (OAAB12500) - OAAB12500 from Aviva Systems Biology
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TULP1 antibody - 70R-21064 from Fitzgerald
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TULP1 antibody (OAGA00273) - OAGA00273 from Aviva Systems Biology
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TULP1 antibody - 70R-12766 from Fitzgerald
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