TULP1

Gene Symbol TULP1
Entrez Gene 7287
Alt Symbol LCA15, RP14, TUBL1
Species Human
Gene Type protein-coding
Description tubby like protein 1
Other Description tubby-related protein 1
Swissprots O43536 Q5TGM5 Q8N571 O00294
Accessions AAB97966 EAX03839 EAX03840 O00294 AB593123 BAJ84063 AB593124 BAJ84064 BC032714 AAH32714 BC065261 AAH65261 CN355966 DQ426893 ABD90544 EU446712 ABZ92241 U82468 AAB53700 NM_001289395 NP_001276324 NM_003322 NP_003313
Function Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:16303976, ECO:0000269|PubMed:19837063}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16303976}. Cell membrane {ECO:0000269|PubMed:16303976}; Peripheral membrane protein {ECO:0000269|PubMed:16303976}; Cytoplasmic side {ECO:0000269|PubMed:16303976}. Secreted {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By similarity). {ECO:0000250}.
Tissue Specificity Retina-specific.

TULP1-Over-expression-Lysate - LY14772a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag TULP1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TULP1 gene.

TULP1 (h): 293T Lysate - sc-115283 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

TULP1 (h2): 293T Lysate - sc-117071 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Panoply™ Human TULP1 Knockdown Stable Cell Line - CSC-DC016872 from Creative biogene

Category Cell Line
Species Human
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