Gene Symbol | TULP1 |
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Entrez Gene | 7287 |
Alt Symbol | LCA15, RP14, TUBL1 |
Species | Human |
Gene Type | protein-coding |
Description | tubby like protein 1 |
Other Description | tubby-related protein 1 |
Swissprots | O43536 Q5TGM5 Q8N571 O00294 |
Accessions | AAB97966 EAX03839 EAX03840 O00294 AB593123 BAJ84063 AB593124 BAJ84064 BC032714 AAH32714 BC065261 AAH65261 CN355966 DQ426893 ABD90544 EU446712 ABZ92241 U82468 AAB53700 NM_001289395 NP_001276324 NM_003322 NP_003313 |
Function | Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:16303976, ECO:0000269|PubMed:19837063}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16303976}. Cell membrane {ECO:0000269|PubMed:16303976}; Peripheral membrane protein {ECO:0000269|PubMed:16303976}; Cytoplasmic side {ECO:0000269|PubMed:16303976}. Secreted {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By similarity). {ECO:0000250}. |
Tissue Specificity | Retina-specific. |
Human TULP1 protein fragment - ab131704 from Abcam
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TULP1 Antibody Blocking Peptide - LS-E4713 from LifeSpan Bioscience
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TULP1 Antibody Blocking Peptide - LS-E11823 from LifeSpan Bioscience
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TULP1 Recombinant Protein - H00007287-P01 from Novus Biologicals
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Recombinant Human TULP1 Protein - NBP2-22896 from Novus Biologicals
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TULP1-Antibody-Center-Blocking-Peptide - BP17083c from Abgent, a WuXi AppTec company
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Human TULP1 protein - orb169489 from Biorbyt
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TULP1 protein (His tag) - 80R-2424 from Fitzgerald
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TULP1 (290-542, His-tag) - AR50504PU-N from Acris Antibodies
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TULP1 (290-542, His-tag) - AR50504PU-S from Acris Antibodies
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TULP1 - H00007287-P01 from Acris Antibodies
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TULP1, 290-542aa, Human, His tag, E.coli - 01-P1680 from ARP American Research Products
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TULP1 fusion protein - ag4478 from Proteintech Group
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TULP1 fusion protein - Ag5598 from Proteintech Group
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TULP1 Human - PRPS-1198 from NeoScientific
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TULP1, 290-542aa, Recombinant Protein - GWB-P0358G from Genway Biotech
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TULP1 - PAT-80570-2 from Nordic BioSite
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TULP1 - PAT-80570-1 from Nordic BioSite
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Recombinant Human Tubby-related protein 1(TULP1) - CSB-YP025346HU CSB-EP025346HU CSB-BP025346HU CSB-MP025346HU from Cusabio
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TuLP1, 290-542aa, Human, His tag, E.coli - ATGP1680 from ATGen
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TULP1 Peptide, Human - M34GP16872H from Creative Peptides
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