| Gene Symbol |
LPAR3
|
| Entrez Gene |
23566
|
| Alt Symbol |
EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidic acid receptor 3
|
| Other Description |
LPA receptor 3|LPA receptor EDG7|LPA-3|calcium-mobilizing lysophosphatidic acid receptor LP-A3|endothelial cell differentiation gene 7|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7|lysophosphatidic acid receptor Edg-7
|
| Swissprots |
A0AVA3 Q9UBY5
|
| Accessions |
CCV20023 EAW73222 Q9UBY5 AF127138 AAD56311 AF186380 AAF00530 AF236117 AAF91291 AK091731 AK308283 AY322547 AAP84360 BC126268 AAI26269 BC126270 AAI26271 BC144021 BU633960 XM_011541149 XP_011539451 NM_012152 NP_036284
|
| Function |
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
|
| Top Pathways |
PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction
|
![Western Blot: EDG7 Overexpression Lysate (Adult Normal) [NBL1-12646] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EDG7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11727_EDG7%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-12646-img0002.jpg)