Gene Symbol | LPAR3 |
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Entrez Gene | 23566 |
Alt Symbol | EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3 |
Species | Human |
Gene Type | protein-coding |
Description | lysophosphatidic acid receptor 3 |
Other Description | LPA receptor 3|LPA receptor EDG7|LPA-3|calcium-mobilizing lysophosphatidic acid receptor LP-A3|endothelial cell differentiation gene 7|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7|lysophosphatidic acid receptor Edg-7 |
Swissprots | A0AVA3 Q9UBY5 |
Accessions | CCV20023 EAW73222 Q9UBY5 AF127138 AAD56311 AF186380 AAF00530 AF236117 AAF91291 AK091731 AK308283 AY322547 AAP84360 BC126268 AAI26269 BC126270 AAI26271 BC144021 BU633960 XM_011541149 XP_011539451 NM_012152 NP_036284 |
Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes. |
Top Pathways | PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction |
EDG-7 CRISPR/Cas9 KO Plasmid (h) - sc-404930 from Santa Cruz Biotechnology
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EDG-7 HDR Plasmid (h) - sc-404930-HDR from Santa Cruz Biotechnology
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EDG-7 Double Nickase Plasmid (h) - sc-404930-NIC from Santa Cruz Biotechnology
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EDG-7 Double Nickase Plasmid (h2) - sc-404930-NIC-2 from Santa Cruz Biotechnology
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EDG-7 CRISPR Activation Plasmid (h) - sc-404930-ACT from Santa Cruz Biotechnology
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EDG-7 CRISPR Activation Plasmid (h2) - sc-404930-ACT-2 from Santa Cruz Biotechnology
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EDG-7 Lentiviral Activation Particles (h) - sc-404930-LAC from Santa Cruz Biotechnology
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EDG-7 Lentiviral Activation Particles (h2) - sc-404930-LAC-2 from Santa Cruz Biotechnology
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EDG-7 siRNA (h) - sc-37088 from Santa Cruz Biotechnology
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EDG-7 shRNA Plasmid (h) - sc-37088-SH from Santa Cruz Biotechnology
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EDG-7 shRNA (h) Lentiviral Particles - sc-37088-V from Santa Cruz Biotechnology
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LPAR3/LPA3/EDG-7 RNAi - H00023566-R02 from Novus Biologicals
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MISSION® esiRNA - EHU055171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12643 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12643 from Sigma-Aldrich
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LPAR3 siRNA (Human) - CRH8366 from Cohesion Biosciences
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Human LPAR3 siRNA - orb268868 from Biorbyt
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LPAR3 shRNA Plasmid (Human) - CHH8366 from Cohesion Biosciences
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LPAR3 miRNA 3'UTR clone - MiUTR3H-07377 from Creative biogene
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