| Gene Symbol |
SNRPB
|
| Entrez Gene |
6628
|
| Alt Symbol |
CCMS, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small nuclear ribonucleoprotein polypeptides B and B1
|
| Other Description |
B polypeptide of Sm protein|Sm protein B/B'|sm-B/Sm-B'|small nuclear ribonucleoprotein polypeptide B|small nuclear ribonucleoprotein polypeptides B and B'|small nuclear ribonucleoprotein-associated proteins B and B'
|
| Swissprots |
Q9UIS5 Q15490 P14678 Q6IB35
|
| Accessions |
AAD54488 AAD54489 CAA37170 CAA37171 CAH05601 EAX10596 EAX10597 EAX10598 EAX10599 P14678 AK301034 BAG62648 AK301206 BAG62782 AK307093 AK307266 AK312620 BAG35506 AY742712 AAU89981 BC003530 BC080516 AAH80516 BM559678 CR456969 CAG33250 HQ447543 ADQ32029 J04564 AAA60151 M34081 AAA36578 M34082 AAA36579 X15893 CAA33902 X17567 CAB57867 X17568 CAB57868 NM_003091 NP_003082 NM_198216 NP_937859
|
| Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:18984161}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
|
| Top Pathways |
Systemic lupus erythematosus, Spliceosome
|